| 词条 | Paul Marks (scientist) |
| 释义 |
| name = | image = | birth_date = {{birth date |1926|08|16}} | birth_place = Brooklyn, New York | death_date = | death_place = | death_cause = | citizenship = | nationality = | fields = | workplaces = {{plainlist|
}} | education = | alma_mater = {{plainlist|
}} | known_for = Paul Marks Prize for Cancer Research | awards = | spouse = | children = }}Paul A. Marks is a medical doctor, researcher and administrator. He is a faculty member and president emeritus at Memorial Sloan Kettering Cancer Center.[1][2] BackgroundMarks was born in Brooklyn, New York, in 1926. Marks attended Columbia College and Columbia Medical School. After completing postdoctoral research at the United States National Institutes of Health and at the Institut Pasteur in France, he joined the faculty at Columbia University. Marks served as dean of the Medical Faculty at Columbia University from 1970 to 1973.[3] He was president and chief executive officer at Memorial Sloan Kettering from 1980 until 1999.[3] Scholarly activitiesMarks has contributed to the fields of genetics and oncology.[3] His recent work has focused on histone deacetylases (HDACs) and chemicals that interfere with HDAC enzymatic activities (HDAC inhibitors or HDIs). Marks and others have found that drugs such as Trichostatin A and SAHA (vorinostat) can serve as anticancer agents.[4] Marks has published more than 400 scientific articles and has been the editor-in-chief of journals including the Journal of Clinical Investigation and Blood.[5] Honors and affiliations
Paul Marks Prize for Cancer ResearchThe Paul Marks Prize for Cancer Research was established by Memorial Sloan Kettering to honor Marks's contributions "as a distinguished scientist and leader".[3] The prize has been awarded every two years since 2001. References1. ^Memorial Sloan Kettering Cancer Center biography {{Authority control}}{{DEFAULTSORT:Marks, Paul}}2. ^Businessweek profile 3. ^1 2 3 4 5 6 MSKCC Paul Marks Prize website 4. ^{{Cite journal | last1 = Marks | first1 = P. A. | last2 = Breslow | first2 = R. | doi = 10.1038/nbt1272 | title = Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug | journal = Nature Biotechnology | volume = 25 | issue = 1 | pages = 84–90 | year = 2007 | pmid = 17211407 | pmc = }} 5. ^1 2 PTC Therapeutics {{webarchive|url=https://web.archive.org/web/20141002022407/http://www.ptcbio.com/marks |date=2014-10-02 }} 8 : American geneticists|American oncologists|1926 births|Living people|Columbia University faculty|Columbia University College of Physicians and Surgeons alumni|Scientists from New York (state)|Fellows of the AACR Academy |
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