Pecos Bill is a mythical American cowboy.

Pecos Bill may also refer to:

• Pecos Bill (comics), an Italian comic series
• Pecos Bill (album), a 1988 album by Robin Williams
• The Greatest Cowboy of All Time, a 1937 novel by James Cloyd Bowman
• Pecos Bill, a segment of the 1948 animated feature Melody Time
• William Rufus Shafter (known by his nickname as "Pecos Bill"), a U.S. Army general

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