| 词条 | Pestivirus NS3 polyprotein peptidase |
| 释义 |
| Name = Pestivirus NS3 polyprotein peptidase | EC_number = 3.4.21.113 | CAS_number = | IUBMB_EC_number = 3/4/21/113 | GO_code = | image = | width = | caption = }}Pestivirus NS3 polyprotein peptidase ({{EC number|3.4.21.113}}, border disease virus NS3 endopeptidase, BDV NS3 endopeptidase, bovine viral diarrhea virus NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3 endopeptidase, p80) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites The genomes of Cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80). References1. ^{{cite journal | vauthors = Wiskerchen M, Collett MS | title = Pestivirus gene expression: protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing | journal = Virology | volume = 184 | issue = 1 | pages = 341–50 | date = September 1991 | pmid = 1651596 | doi = 10.1016/0042-6822(91)90850-b }} 2. ^{{cite journal | vauthors = Tautz N, Elbers K, Stoll D, Meyers G, Thiel HJ | title = Serine protease of pestiviruses: determination of cleavage sites | journal = Journal of Virology | volume = 71 | issue = 7 | pages = 5415–22 | date = July 1997 | pmid = 9188613 | pmc = 191781 }} 3. ^{{cite journal | vauthors = Xu J, Mendez E, Caron PR, Lin C, Murcko MA, Collett MS, Rice CM | title = Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication | journal = Journal of Virology | volume = 71 | issue = 7 | pages = 5312–22 | date = July 1997 | pmid = 9188600 | pmc = 191768 }} 4. ^{{cite journal | vauthors = Tautz N, Kaiser A, Thiel HJ | title = NS3 serine protease of bovine viral diarrhea virus: characterization of active site residues, NS4A cofactor domain, and protease-cofactor interactions | journal = Virology | volume = 273 | issue = 2 | pages = 351–63 | date = August 2000 | pmid = 10915606 | doi = 10.1006/viro.2000.0425 }} External links
1 : EC 3.4.21 |
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