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词条 Peter Colman
释义

  1. Education

  2. Research and career

     Awards and honours 

  3. References

{{EngvarB|date=August 2017}}{{Use dmy dates|date=August 2017}}{{Infobox scientist
| name = Peter Colman
| honorific_suffix = {{post-nominals|country=AUS|AC|FRS|FAA|FTSE|size=100%}}
| birth_name = Peter Malcolm Colman
| image = Professor_Peter_Colman_FRS.jpg
| image_size =
| alt =
| caption = Peter Colman at the Royal Society admissions day in 2014
| birth_date = {{Birth date and age|df=yes|1944|4|3}}[1]
| birth_place = Adelaide[2]
| other_names =
| residence =
| citizenship =
| nationality =
| fields = {{Plainlist|
  • Structural biology
  • Viral neuraminidases}}

| workplaces = {{Plainlist|
  • University of Oregon
  • University of Sydney
  • University of Melbourne
  • La Trobe University
  • Walter and Eliza Hall Institute of Medical Research
  • CSIRO[1]}}

| patrons =
| alma_mater = {{Plainlist|
  • University of Adelaide (BSc, PhD)}}

| thesis_title = The physical structure of two parabanic acid complexes and an investigation of short intermolecular carbon-oxygen contacts
| thesis_url = http://hdl.handle.net/2440/19998
| thesis_year = 1969
| doctoral_advisor = Harry Medlin[4]
| academic_advisors =
| doctoral_students =
| notable_students =
| known_for = {{Plainlist|
  • Zanamivir (Relenza)
  • Oseltamivir (Tamiflu)[2]}}

| influences = {{Plainlist|
  • Robert Huber[1][7]
  • Hans Freeman[1][3]}}

| influenced =
| awards = {{Plainlist|
  • Florey Medal (2004)[4]
  • Centenary Medal (2001)[11]
  • James Cook Medal (1999)
  • Australia Prize (1996)}}

| website = {{URL|wehi.edu.au/faculty_members/professor_peter_colman}}
| footnotes =
| spouse =
| children =

}}Peter Malcolm Colman {{post-nominals|country=AUS|AC|FRS|FAA|FTSE}} (born 1944)[5] is the head of the structural biology division at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia.[6]

Education

Colman was educated at the University of Adelaide, where he received a Bachelor of Science degree in physics in 1966[5] and a PhD in 1969 for research on the chemical structure of parabanic acid complexes supervised by Harry Medlin.[7]

Research and career

Colman's research interests are in structural biology,[8][9][10] especially of human B-cell lymphoma 2 (BCL-2).[11][12][13][14] Colman determined the three-dimensional structure of the influenza virus neuraminidase and, in one of the earliest cases of structure-based drug design, discovered zanamivir, the first-in-class neuraminidase inhibitor for influenza.[23] His subsequent structural studies on resistance to this drug class suggested how to design drugs against moving targets.[23] His discoveries underpin drug stockpiling for pandemic preparedness.[23] He has made seminal contributions to structural studies of antibodies and antibody-antigen complexes.[23] Recent{{when|date=September 2018}} work on apoptosis solves the long-standing problem of how pro-apoptotic Bax changes conformation to dimerise and then oligomerise and permeabilise the mitochondrial membrane, an essential step in the intrinsic cell-death pathway.[15]

His work has been published in leading peer reviewed scientific journals including Nature,[8][16][17][18][19][20] the Journal of Molecular Biology,[21] and Nature Reviews Molecular Cell Biology.[22]

Awards and honours

In the Queen's 2017 Birthday Honours Colman was appointed a Companion of the Order of Australia (AC), Australia's highest civilian honour, "for eminent service to medical research, particularly in the fields of structural biology and medicinal chemistry, as a leader in the commercial translation of scientific discoveries, to professional organisations, and as a mentor of young scientists".[23]

Colman was elected a Fellow of the Royal Society (FRS) in 2014.[15] In 2001 he was awarded a Centenary Medal "For service to Australian society and science in structural biology".[24] Colman was also elected a Fellow of the Australian Academy of Science in 1989 and a Fellow of the Australian Academy of Technological Sciences and Engineering in 1997.[5] He was awarded the Macfarlane Burnet Medal and Lecture in 1995.[25]

References

1. ^1 2 3 Peter Malcolm Colman, CSIROpedia, Commonwealth Scientific and Industrial Research Organisation
2. ^{{Cite journal | pmid = 7849585| pmc = 2142611| year = 1994| author1 = Colman| first1 = P. M.| title = Influenza virus neuraminidase: Structure, antibodies, and inhibitors| journal = Protein Science| volume = 3| issue = 10| pages = 1687–96| doi = 10.1002/pro.5560031007}}
3. ^{{Cite journal | doi = 10.1038/272319a0| title = X-ray crystal structure analysis of plastocyanin at 2.7 Å resolution| journal = Nature| volume = 272| issue = 5651| pages = 319| year = 1978| last1 = Colman | first1 = P. M.| authorlink1 = Peter Colman| last2 = Freeman | first2 = H. C.| authorlink2 =Hans Freeman| last3 = Guss | first3 = J. M.| last4 = Murata | first4 = M.| last5 = Norris | first5 = V. A.| last6 = Ramshaw | first6 = J. A. M.| last7 = Venkatappa | first7 = M. P.}}
4. ^{{cite web|url=http://www.aips.net.au/news-events/the-florey-medal/2004-prof-peter-colman/ |title=Professor Peter Colman|publisher=Australian Institute of Policy and Science|website=aips.net}}
5. ^1 2 3 {{Who's Who | surname = Colman | othernames = Dr Peter Malcolm | author=Anon| id = U23546 | doi =10.1093/ww/9780199540884.013.U23546 | year = 2014 | edition = online Oxford University Press}} {{subscription required}}
6. ^{{Scopus id}}
7. ^1 {{cite thesis |degree=PhD |first=Peter Malcolm|last=Colman |title=The physical structure of two parabanic acid complexes and an investigation of short intermolecular carbon-oxygen contacts |year=1969 |url=http://trove.nla.gov.au/version/7213869|authorlink=Peter Colman|publisher=University of Adelaide|oclc=222734513|website=trove.nla.gov.au|hdl=2440/19998}} {{free access}}
8. ^1 2 {{Cite journal | doi = 10.1038/264415a0| pmid = 1004567| title = Crystallographic structure studies of an IgG molecule and an Fc fragment| journal = Nature| volume = 264| issue = 5585| pages = 415–20| year = 1976| last1 = Huber | first1 = R. | authorlink1 = Robert Huber| last2 = Deisenhofer | first2 = J. | authorlink2 = Johann Deisenhofer| last3 = Colman | first3 = P. M. | authorlink3 = Peter Colman| last4 = Matsushima | first4 = M. | last5 = Palm | first5 = W. }}
9. ^{{Cite journal | doi = 10.1016/S0923-2494(94)80039-1| pmid = 7516563| title = Effects of amino acid sequence changes on antibody-antigen interactions| journal = Research in Immunology| volume = 145| issue = 1| pages = 33–6| year = 1994| last1 = Colman | first1 = P. M. }}
10. ^{{YouTube|id=FPR5jFHiexg|title=Type 1 Diabetes Research Update – with Professor Peter Colman}}
11. ^{{Cite journal | doi = 10.1038/nrd2658| pmid = 19043450| title = BCL-2 family antagonists for cancer therapy| journal = Nature Reviews Drug Discovery| volume = 7| issue = 12| pages = 989| year = 2008| last1 = Lessene | first1 = G. | last2 = Czabotar | first2 = P. E. | last3 = Colman | first3 = P. M. }}
12. ^{{Cite journal | doi = 10.1021/jm401948b| pmid = 24456288| title = De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization| journal = Journal of Medicinal Chemistry| volume = 57| issue = 4| pages = 1323| year = 2014| last1 = Brady | first1 = R. M. | last2 = Vom | first2 = A. | last3 = Roy | first3 = M. J. | last4 = Toovey | first4 = N. | last5 = Smith | first5 = B. J. | last6 = Moss | first6 = R. M. | last7 = Hatzis | first7 = E. | last8 = Huang | first8 = D. C. S. | last9 = Parisot | first9 = J. P. | last10 = Yang | first10 = H. | last11 = Street | first11 = I. P. | last12 = Colman | first12 = P. M. | last13 = Czabotar | first13 = P. E. | last14 = Baell | first14 = J. B. | last15 = Lessene | first15 = G. }}
13. ^{{Cite journal | doi = 10.1021/ml500030p| pmid = 24944740| title = Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL| journal = ACS Medicinal Chemistry Letters| volume = 5| issue = 6| pages = 662| year = 2014| last1 = Koehler | first1 = M. F. T. | last2 = Bergeron | first2 = P. | last3 = Choo | first3 = E. F. | last4 = Lau | first4 = K. | last5 = Ndubaku | first5 = C. | last6 = Dudley | first6 = D. | last7 = Gibbons | first7 = P. | last8 = Sleebs | first8 = B. E. | last9 = Rye | first9 = C. S. | last10 = Nikolakopoulos | first10 = G. | last11 = Bui | first11 = C. | last12 = Kulasegaram | first12 = S. | last13 = Kersten | first13 = W. J. A. | last14 = Smith | first14 = B. J. | last15 = Czabotar | first15 = P. E. | last16 = Colman | first16 = P. M. | last17 = Huang | first17 = D. C. S. | last18 = Baell | first18 = J. B. | last19 = Watson | first19 = K. G. | last20 = Hasvold | first20 = L. | last21 = Tao | first21 = Z. F. | last22 = Wang | first22 = L. | last23 = Souers | first23 = A. J. | last24 = Elmore | first24 = S. W. | last25 = Flygare | first25 = J. A. | last26 = Fairbrother | first26 = W. J. | last27 = Lessene | first27 = G. | pmc=4060937}}
14. ^{{Cite journal | doi = 10.1016/j.molcel.2004.12.030| pmid = 15694340| title = Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function| journal = Molecular Cell| volume = 17| issue = 3| pages = 393–403| year = 2005| last1 = Chen | first1 = L. | last2 = Willis | first2 = S. N. | last3 = Wei | first3 = A. | last4 = Smith | first4 = B. J. | last5 = Fletcher | first5 = J. I. | last6 = Hinds | first6 = M. G. | last7 = Colman | first7 = P. M. | last8 = Day | first8 = C. L. | last9 = Adams | first9 = J. M. | last10 = Huang | first10 = D. C. S. }}
15. ^1 2 3 4 5 {{cite web |archiveurl= https://web.archive.org/web/20150505083411/https://royalsociety.org/people/fellowship/2014/peter-colman/ |archivedate=2015-05-05 |url=https://royalsociety.org/people/peter-colman-11253/ |title = Professor Peter Colman FRS |publisher=Royal Society|website=royalsociety.org|author=Anon|year=2014 |location=London}} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{quote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{Webarchive|url=https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/|title=Royal Society Terms, conditions and policies|date=2016-11-11}}}}
16. ^{{Cite journal | doi = 10.1038/363418a0| pmid = 8502295| title = Rational design of potent sialidase-based inhibitors of influenza virus replication| journal = Nature| volume = 363| issue = 6428| pages = 418–23| year = 1993| last1 = von Itzstein | first1 = M. | last2 = Wu | first2 = W. Y. | last3 = Kok | first3 = G. B. | last4 = Pegg | first4 = M. S. | last5 = Dyason | first5 = J. C. | last6 = Jin | first6 = B. | last7 = Phan | first7 = T. V. | last8 = Smythe | first8 = M. L. | last9 = White | first9 = H. F. | last10 = Oliver | first10 = S. W. | last11 = Colman | first11 = P. M. | last12 = Varghese | first12 = J. N. | last13 = Ryan | first13 = D. M. | last14 = Woods | first14 = J. M. | last15 = Bethell | first15 = R. C. | last16 = Hotham | first16 = V. J. | last17 = Cameron | first17 = J. M. | last18 = Penn | first18 = C. R. }}
17. ^{{Cite journal | last1 = Chothia | first1 = C. | authorlink1 = Cyrus Chothia| last2 = Lesk | first2 = A. M. | authorlink2 = Arthur M. Lesk| last3 = Tramontano | first3 = A. | last4 = Levitt | first4 = M. | authorlink4 = Michael Levitt| last5 = Smith-Gill | first5 = S. J. | last6 = Air | first6 = G. | last7 = Sheriff | first7 = S. | last8 = Padlan | first8 = E. A. | last9 = Davies | first9 = D. | last10 = Tulip | doi = 10.1038/342877a0 | first10 = W. R. | last11 = Colman | first11 = P. M. | authorlink11 = Peter Colman| last12 = Spinelli | first12 = S. | last13 = Alzari | first13 = P. M. | last14 = Poljak | first14 = R. J. | title = Conformations of immunoglobulin hypervariable regions | journal = Nature | volume = 342 | issue = 6252 | pages = 877–883 | year = 1989 | pmid = 2687698 |bibcode = 1989Natur.342..877C }}
18. ^{{Cite journal | doi = 10.1038/303035a0| pmid = 6843658| title = Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution| journal = Nature| volume = 303| issue = 5912| pages = 35–40| year = 1983| last1 = Varghese | first1 = J. N.| last2 = Laver | first2 = W. G.| last3 = Colman | first3 = P. M.}}
19. ^{{Cite journal | doi = 10.1038/326358a0| pmid = 2436051| title = Three-dimensional structure of a complex of antibody with influenza virus neuraminidase| journal = Nature| volume = 326| issue = 6111| pages = 358| year = 1987| last1 = Colman | first1 = P. M.| last2 = Laver | first2 = W. G.| last3 = Varghese | first3 = J. N.| last4 = Baker | first4 = A. T.| last5 = Tulloch | first5 = P. A.| last6 = Air | first6 = G. M.| last7 = Webster | first7 = R. G.}}
20. ^{{Cite journal | doi = 10.1038/303041a0| pmid = 6188957| title = Structure of the catalytic and antigenic sites in influenza virus neuraminidase| journal = Nature| volume = 303| issue = 5912| pages = 41–4| year = 1983| last1 = Colman | first1 = P. M.| last2 = Varghese | first2 = J. N.| last3 = Laver | first3 = W. G.}}
21. ^{{Cite journal | doi = 10.1006/jmbi.1993.1648| pmid = 8263940| title = Shape Complementarity at Protein/Protein Interfaces| journal = Journal of Molecular Biology| volume = 234| issue = 4| pages = 946| year = 1993| last1 = Lawrence | first1 = M. C. | last2 = Colman | first2 = P. M. }}
22. ^{{Cite journal | doi = 10.1038/nrm1076| pmid = 12671653| title = The structural biology of type I viral membrane fusion| journal = Nature Reviews Molecular Cell Biology| volume = 4| issue = 4| pages = 309–19| year = 2003| last1 = Colman | first1 = P. M. | last2 = Lawrence | first2 = M. C. }}
23. ^Companion (AC) in the General Division of the Order of Australia, Media Notes, Queen's Birthday 2017, www.gg.gov.au
24. ^1 [https://www.itsanhonour.gov.au/honours/honour_roll/search.cfm?breif=false&page=1&search_view=~all~&view=10&search_type=simple COLMAN, Peter Malcolm - Centenary Medal], 1 January 2001, It's an Honour.
25. ^{{cite web|url=https://www.science.org.au/opportunities-scientists/recognition/honorific-awards/career-awards/macfarlane-burnet-medal-and|title=Macfarlane Burnet Medal and Lecture|publisher= Australian Academy of Science|accessdate=2017-02-22}}
{{CC-notice|cc=by4|url=https://royalsociety.org/people/peter-colman-11253}}{{FRS 2014}}{{Authority control}}{{DEFAULTSORT:Colman, Peter Malcolm}}

8 : 1944 births|Living people|Fellows of the Royal Society|Australian medical researchers|Companions of the Order of Australia|Recipients of the Centenary Medal|Fellows of the Australian Academy of Science|Fellows of the Australian Academy of Technological Sciences and Engineering
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