| 词条 | PHA-57378 |
| 释义 |
| IUPAC_name = 2,7,8,9,10,11-hexahydro-1H-azepino[4,5-b][1,4]oxazino[2,3,4-hi]indole | image = PHA-57378_structure.png | width = 240 | tradename = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 303798-94-9 | PubChem = 10198481 | ChemSpiderID = 8373981 | C=14 | H=16 | N=2 | O=1 | molecular_weight = 228.29 g/mol | smiles = C1(OCC2)=C(N2C3=C4CCNCC3)C4=CC=C1 | StdInChI = 1S/C14H16N2O/c1-2-11-10-4-6-15-7-5-12(10)16-8-9-17-13(3-1)14(11)16/h1-3,15H,4-9H2 | StdInChIKey = KMVAXNRPZRSLSY-UHFFFAOYSA-N }}PHA-57378 is a drug which acts as an agonist at serotonin 5-HT2 receptors,[1] having a binding affinity of 4.1 nM at the 5-HT2A subtype and 4.3 nM at 5-HT2C. It has anxiolytic effects in animal studies.[2] See also
References1. ^Jackson Hester et al. TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS. WIPO Patent Application WO 2000/064899, Priority date April 23, 1999 {{Serotonergics}}{{nervous-system-drug-stub}}2. ^{{Cite journal | last1 = Ennis | first1 = M. D. | last2 = Hoffman | first2 = R. L. | last3 = Ghazal | first3 = N. B. | last4 = Olson | first4 = R. M. | last5 = Knauer | first5 = C. S. | last6 = Chio | first6 = C. L. | last7 = Hyslop | first7 = D. K. | last8 = Campbell | first8 = J. E. | last9 = Fitzgerald | first9 = L. W. | last10 = Nichols | first10 = N. F. | last11 = Svensson | first11 = K. A. | last12 = McCall | first12 = R. B. | last13 = Haber | first13 = C. L. | last14 = Kagey | first14 = M. L. | last15 = Dinh | first15 = D. M. | title = 2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-\\1,4]diazepino\\1,7-a]indoles: New templates for 5-HT2C agonists | doi = 10.1016/S0960-894X(03)00403-7 | journal = Bioorganic & Medicinal Chemistry Letters | volume = 13 | issue = 14 | pages = 2369–72 | year = 2003 | pmid = 12824036| pmc = }} 2 : Serotonin receptor agonists|Indoles |
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