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词条 Piscarinine
释义

  1. References

{{Orphan|date=November 2013}}Piscarinines are bioactive alkaloid isolates of Penicillium piscarium NKM F-961 [1] and Penicillium piscarium Westling [2] that belong to a class of naturally occurring 2,5-diketopiperazines.[3]

The cytotoxic dehydroproline tryptophan derivatives piscarinines A and B were shown to be active against the prostate cancer cell line LNCAP [2] (IC50 values were 2.2 and 1.9 μg/mL for piscarinine A and B, respectively).

References

1. ^{{Cite journal | title = Piscarinines, new polycyclic diketopiperazine alkaloids from Penicillium piscarium NKM F-691 |vauthors=Kozlovsky A, Vinokurova NG, Adanin VM, Gräfe U | journal = Natural Product Letters | year = September 2000 | volume = 14 | issue = 5 | pages = 333–340| doi = 10.1080/10575630008043765}}
2. ^{{cite journal |vauthors=Zhelifonova VP, Maier A, Kozlovskii AG | title = Effect of various factors on the biosynthesis of piscarinines, secondary metabolites of the fungus Penicillium piscarium Westling | journal = Applied biochemistry and microbiology | volume = 44 | issue = 6 | pages = 608–612 |date= November 2008 | pmid = 19145974 | doi = 10.1134/S0003683808060082 | url = }}
3. ^{{Cite journal | title = 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products | author = Borthwick AD | journal = Chemical Reviews | year = May 2012 | volume = 112 | issue = 7 | pages = 3641–3716 | doi = 10.1021/cr200398y | pmid = 22575049}}

3 : Diketopiperazines|Alkaloids|Penicillium

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