| 词条 | Plasmepsin I |
| 释义 |
| Name = Plasmepsin I | EC_number = 3.4.23.38 | CAS_number = 180189-87-1 | IUBMB_EC_number = 3/4/23/38 | GO_code = | image = | width = | caption = }}Plasmepsin I ({{EC number|3.4.23.38}}, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction Hydrolysis of the -Phe33-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule This enzyme is present in the malaria organism, Plasmodium. References1. ^{{cite journal | vauthors = Goldberg DE, Slater AF, Beavis R, Chait B, Cerami A, Henderson GB | title = Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease | journal = The Journal of Experimental Medicine | volume = 173 | issue = 4 | pages = 961–9 | date = April 1991 | pmid = 2007860 | pmc = 2190804 | doi = 10.1084/jem.173.4.961 }} 2. ^{{cite journal | vauthors = Francis SE, Gluzman IY, Oksman A, Knickerbocker A, Mueller R, Bryant ML, Sherman DR, Russell DG, Goldberg DE | title = Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase | journal = The EMBO Journal | volume = 13 | issue = 2 | pages = 306–17 | date = January 1994 | pmid = 8313875 | pmc = 394809 | doi = 10.1002/j.1460-2075.1994.tb06263.x }} 3. ^{{cite journal | vauthors = Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE | title = Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway | journal = The Journal of Clinical Investigation | volume = 93 | issue = 4 | pages = 1602–8 | date = April 1994 | pmid = 8163662 | pmc = 294190 | doi = 10.1172/JCI117140 }} External links
1 : EC 3.4.23 |
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