“PLEKHM3”的意思、由来-开放百科全书

词条

PLEKHM3

释义

Gene
Protein
Function Interactions
References
External links

Pleckstrin Homology domain containing Family M Member 3, or PLEKHM3, is the hypothetical protein that in humans is encoded by the PLEKHM3 gene.^[1] PLEKHM3 is also known as DAPR (differentiation associated protein), and Pleckstrin Homology Domain Containing Family M, Member 1-like.^[2]

Gene

PLEKHM3 is a valid, protein coding gene that is located on the minus strand of the q-arm of chromosome 2. Its exact location is 2q33.3. Its genomic mRNA length is 9,807 base pairs.

Its genomic DNA length is 24.3 kilobases. It has 8 exons, 4 common splice forms.

Protein

PLEKHM3 contains 3 domains. Two domains are highly conserved across mammalian species. The most highly conserved region is the DUF4206 Domain. The third is a domain of unknown function 4206, which is highly conserved across all eukarya.^[3] Its molecular weight is 87.2 kilodaltons. Its isoelectric point is 6.81. It is predicted to be localized primarily in the cytosol.^[4] PLEKHM3 has orthologs in eukaryotes.

Function

The function of PLEKHM3 is not characterized in any scientific database. It is thought to be associated with cell differentiation and is expressed at ubiquitously low levels in all cell types. The Pleckstrin Homology domains are involved with phosphate binding. The DUF4206 Domain is cysteine rich and forms with 7 CXXC protein motifs. This motif is responsible for forming disulfide bridges. The DUF4206 domain is conserved in PLEKHM3 homologs as distant as Nile Tilapia.

Interactions

PLEKHM3 is thought to interact with a protein called GDAP1, which is responsible for differentiation in neuronal cell types and plays a role in the signal transduction pathway. This also supports the predicted role of PLEKHM3 in differentiation.

References

1. ^{{EntrezGene|51526}}: plekstrin homology domain containing family member 3
2. ^{{cite web|author=GeneCards Human Gene Database |url=http://genecards.org/cgi-bin/carddisp.pl?gene=PLEKHM3&search=plekhm3 |title=PLEKHM3 Gene - GeneCards | PKHM3 Protein | PKHM3 Antibody |publisher=GeneCards |date= |accessdate=2013-05-16}}
3. ^{{cite web|url=http://workbench.sdsc.edu/ |title=SDSC Biology Workbench |publisher=Workbench.sdsc.edu |date= |accessdate=2013-05-16}}
4. ^{{cite web|url=http://psort.hgc.jp/form2.html |title=PSORT II Prediction |publisher=Psort.hgc.jp |date=1999-11-24 |accessdate=2013-05-16}}

External links

[https://www.ncbi.nlm.nih.gov/nuccore/NM_001080475.2 NCBI (National Center for Biotechnology Information)]

1 : Genes on human chromosome 2

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