“Sulfonucleotide reductase”的意思、由来-开放百科全书

词条

Sulfonucleotide reductase

释义

References

{{Orphan|date=February 2009}}Sulfonucleotide reductases are a class of enzymes involved in reductive sulfur assimilation. This reaction consists of a conversion from activated sulfate to sulfite. (Inorganic sulfate occurs abundantly on Earth; terrestrial organisms must use sulfate assimilation to convert it to sulfide). The sulfite is used in essential biomolecules such as cysteine. The sulfonucleotide reductases are through to have all evolved from a common ancestor.^[1]

The enzymes reduce adenosine-5'-phosphosulfate by nucleophilic attack to produce the sulfite product. This typically involves a cofactor (such as an iron-sulphur cluster), however the cofactor varies in different families.^[1]

References

1. ^¹{{Cite journal|last=Carroll|first=Kate S.|last2=Gao|first2=Hong|last3=Chen|first3=Huiyi|last4=Stout|first4=C. David|last5=Leary|first5=Julie A.|last6=Bertozzi|first6=Carolyn R.|date=2005-07-19|title=A Conserved Mechanism for Sulfonucleotide Reduction|url=http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0030250|journal=PLOS Biology|volume=3|issue=8|pages=e250|doi=10.1371/journal.pbio.0030250|issn=1545-7885|pmc=1175818}}

1 : Sulfur metabolism

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