| 词条 | Sulforaphane | |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 415694214 | ImageFile = Sulforaphane.png | ImageSize = 200px | ImageFile1 = Sulforaphane-3D-balls.png | ImageFile2 = Sulforaphane-3D-vdW.png | IUPACName = 1-Isothiocyanato-4-methylsulfinylbutane | OtherNames = |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo = 4478-93-7 | PubChem = 5350 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 47807 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 48802 | SMILES = CS(=O)CCCCN=C=S | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 5157 | InChI = 1/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3 | InChIKey = SUVMJBTUFCVSAD-UHFFFAOYAY | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = SUVMJBTUFCVSAD-UHFFFAOYSA-N |Section2={{Chembox Properties | Formula = C6H11NOS2 | MolarMass = 177.29 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Sulforaphane (sulphoraphane in British English) is a compound within the isothiocyanate group of organosulfur compounds.[1] It is obtained from cruciferous vegetables such as broccoli, Brussels sprouts, and cabbages. It is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing), which allows the two compounds to mix and react. Young sprouts of broccoli and cauliflower are particularly rich in glucoraphanin.[1]
Occurrence and isolationSulforaphane occurs in broccoli sprouts, which, among cruciferous vegetables, have the highest concentration of glucoraphanin, the precursor to sulforaphane.[1][2] It is also found in cabbage, cauliflower, Brussels sprouts, bok choy, kale, collards, mustard greens, and watercress.[1] ResearchAlthough there has been some basic research on how sulforaphane might exert beneficial effects in vivo,[3][4] there is no high-quality evidence to date for its efficacy against human diseases.[1][5] See also
References1. ^1 2 3 4 {{cite web |title=Isothiocyanates |url=https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/isothiocyanates |publisher=Micronutrient Information Center, Linus Pauling Institute, Oregon State University |accessdate=19 November 2018 |date=March 2017}} {{Glycosides}}{{HDAC inhibitors}}{{Cruciferous Biochemistry}}2. ^{{cite journal |pmid=24147970|year=2013|last1=Houghton|first1=C. A.|title=Sulforaphane: Translational research from laboratory bench to clinic|journal=Nutrition Reviews|volume=71|issue=11|pages=709–26|last2=Fassett|first2=R. G.|last3=Coombes|first3=J. S.|doi=10.1111/nure.12060}} 3. ^{{cite journal |vauthors=Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P |title=Sulforaphane as a potential protective phytochemical against neurodegenerative diseases |journal=Oxid Med Cell Longev |volume=2013 |issue= |pages=415078 |year=2013 |pmid=23983898 |pmc=3745957 |doi=10.1155/2013/415078 |type=Review}} 4. ^{{cite journal |vauthors=Moon JK, Kim JR, Ahn YJ, Shibamoto T | title = Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli ( Brassica oleracea L.) sprouts | journal = J. Agric. Food Chem. | volume = 58 | issue = 11 | pages = 6672–7 | year = 2010 | pmid = 20459098 | doi = 10.1021/jf1003573 }} 5. ^{{cite journal|last1=van Die|first1=MD|last2=Bone|first2=KM|last3=Emery|first3=J|last4=Williams|first4=SG|last5=Pirotta|first5=MV|last6=Paller|first6=CJ|title=Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials|journal=BJU Int.|date=April 2016|volume=117|issue=S4|pages=17-34|doi=10.1111/bju.13361|pmid=26898239}} 4 : Experimental cancer drugs|Isothiocyanates|Sulfoxides|Histone deacetylase inhibitors |
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