Powell Creek or Powells Creek may refer to:

• Powells Creek (Sydney), a tributary of the Parramatta River in Sydney, New South Wales, Australia
• Powell Creek (New York), a tributary of Groves Creek in Seneca County
• Powell Creek (Pennsylvania), a tributary of the Susquehanna River in Dauphin County, Pennsylvania, United States
• Powell Creek, West Virginia, an unincorporated community in Boone County, West Virginia, United States
• Powell's Creek (Prince George County, Virginia), a tributary of the James River in Prince George County, Virginia, United States
• Powells Creek (Prince William County, Virginia), a river near Montclair, Virginia, United States
• Powell's Creek Church, in Hancock County, Georgia, United States

• Reaction to Tim Russert's death
• Reaction to Tim Russert's Death
• Reaction velocity
• Reaction–diffusion
• Reaction–diffusion equation
• Reaction–diffusion equations
• Reactivan
• Reactive Airway Disease
• Reactive airways dysfunction syndrome
• Reactive angioendotheliomatosis
• Reactive armor
• Reactive armore tiles
• Reactive arthropathy
• Reactive astrocyte
• Reactive astrocytes
• Reactive bromine
• Reactive centrifugal force
• Reactive destocking
• Reactive (disambiguation)
• Reactive empirical bond order
• Reactive flash volatilization
• Reactive force
• Reactive glia
• Reactive hyperemia
• Reactive ion etch