| 词条 | PPADS |
| 释义 |
| ImageFile = PPADS.svg | ImageSize = 200px | IUPACName = 4-[(E)- | OtherNames = PPADS |Section1={{Chembox Identifiers | CASNo = 149017-66-3 | CASNo_Ref = {{cascite|correct|CAS}} | CASNo1 = 192575-19-2 | CASNo1_Ref = {{cascite|correct|CAS}} | CASNo1_Comment = (tetrasodium salt) | PubChem = 6093163 | PubChem1 = 6532796 | PubChem1_Comment = (tetrasodium salt) | ChemSpiderID = 20136164 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 34941 | SMILES = Oc2c(C=O)c(COP(O)(=O)O)c(/N=N/c1ccc(cc1S(O)(=O)=O)S(O)(=O)=O)nc2C | InChI = InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28)/b17-16+ |Section2={{Chembox Properties | C=14 | H=14 | N=3 | O=12 | P=1 | S=2 | Appearance = Orange solid | Density = | MeltingPt = | BoilingPt = | Solubility = 100 mM (tetrasodium salt)[1] |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist.[2] It is able to block contractions of rabbit vas deferens induced by ATP or α,β,methylene-ATP. It appears to be relatively selective for P2X receptors, having no appreciable activity at α1 adrenergic, muscarinic M2 and M3, histamine H1, and adenosine A1 receptors.[3] References1. ^PPADS tetrasodium salt, Santa Cruz Biotechnology {{Purinergics}}{{genito-urinary-drug-stub}}2. ^{{cite journal|last=Ziganshin|first=AU|title=PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder.|journal=British Journal of Pharmacology|date=December 1993|volume=110|issue=4|pages=1491–95|pmid=8306091|pmc=2175839|doi=10.1111/j.1476-5381.1993.tb13990.x}} 3. ^{{cite journal|last=Lambrecht|first=G.|title=PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses|journal=European Journal of Pharmacology|year=1992|volume=217|pages=217–19|doi=10.1016/0014-2999(92)90877-7|pmid=1330591}} 4 : Azo compounds|Organophosphates|Pyridines|Sulfonic acids |
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