| 词条 | PPPA (drug) |
| 释义 |
| IUPAC_name = 3-Phenoxy-3-phenyl-1-propanamine | image = 3-phenoxy-3-phenylpropan-1-amine.svg | CAS_number = | ATC_prefix = None | ATC_suffix = | PubChem = | DrugBank = | ChemSpiderID = 14379241 | chemical_formula = | C=15 | H=17 | N=1 | O=1 | molecular_weight = 227.302 g/mol | SMILES = c1ccc(cc1)C(CCN)Oc2ccccc2 | StdInChI = 1S/C15H17NO/c16-12-11-15(13-7-3-1-4-8-13)17-14-9-5-2-6-10-14/h1-10,15H,11-12,16H2 | StdInChIKey = XYWLZHPZECQHMB-UHFFFAOYSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }}PPPA, or 3-phenoxy-3-phenylpropan-1-amine, is a drug which is described as an antidepressant.[1] It was derived by Eli Lilly from the antihistamine diphenhydramine, a 2-diphenylmethoxyethanamine derivative with additional properties as a selective serotonin reuptake inhibitor (SSRI), and has been the basis for the subsequent discovery of a number of other antidepressant drugs.[2][3][4] List of PPPA derivatives
Structurally related drugs include dapoxetine, duloxetine, edivoxetine, femoxetine, paroxetine, reboxetine, and viloxazine, all of which act, similarly, as monoamine reuptake inhibitors, and most of which are, again similarly, antidepressants.[1][3] Zimelidine is an antidepressant and SSRI which was derived from the antihistamine pheniramine, which, similarly to its analogues brompheniramine and chlorpheniramine, possesses SNRI properties.[4] Fluvoxamine, another antidepressant and SSRI, was developed from the antihistamine tripelennamine, which possesses SNDRI actions.[6]See also
References1. ^1 2 3 {{cite book|author1=Thomas L. Lemke|author2=David A. Williams|title=Foye's Principles of Medicinal Chemistry|url=https://books.google.com/books?id=R0W1ErpsQpkC&pg=PA414|year=2008|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-6879-5|pages=414–}} 2. ^1 2 {{cite book|author1=Francisco Lopez-Munoz|author2=Cecilio Alamo|title=Neurobiology of Depression|url=https://books.google.com/books?id=lmXRBQAAQBAJ&pg=PA132|date=9 September 2011|publisher=CRC Press|isbn=978-1-4398-3850-1|pages=132–}} 3. ^1 2 {{cite book|author1=Janos Fischer|author2=C. Robin Ganellin|title=Analogue-based Drug Discovery II|url=https://books.google.com/books?id=h2Kd8ci4Ln8C&pg=PA282|date=24 August 2010|publisher=John Wiley & Sons|isbn=978-3-527-63212-1|pages=35, 282, 284}} 4. ^1 2 {{cite book|author=Walter Sneader|title=Drug Discovery: A History|url=https://books.google.com/books?id=jglFsz5EJR8C&pg=PA416|date=31 October 2005|publisher=John Wiley & Sons|isbn=978-0-470-01552-0|pages=416–417}} 5. ^{{cite book|author=David G. Watson|title=Pharmaceutical Chemistry|url=https://books.google.com/books?id=-lQM4xHjWeUC&pg=PT1061|date=9 February 2011|publisher=Elsevier Health Sciences|isbn=0-7020-4850-X|pages=1061–}} 6. ^{{cite book|author=David Healy|title=Let Them Eat Prozac: The Unhealthy Relationship Between the Pharmaceutical Industry and Depression|url=https://books.google.com/books?id=5w64WC_-jbMC&pg=PA295|date=1 June 2004|publisher=NYU Press|isbn=978-0-8147-7300-0|pages=295–}} Further reading
4 : Amines|Antidepressants|Eli Lilly and Company|Serotonin-norepinephrine reuptake inhibitors |
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