| 词条 | Prati criteria |
| 释义 |
}} The Prati criteria are a revision to the clinical definition of normal serum alanine aminotransferase (ALT) which was published in the Annals of Internal Medicine in 2002.[1] Daniele Prati and colleagues identified that, in the original research which developed guidelines for normal ranges of ALT, the cohort included subjects with subclinical disease such as non-alcoholic fatty liver disease. This led to ranges of 40 U/L in men and 30 U/L in women. This marker had low sensitivity and high specificity due to classification of individuals with subclinical disease counted as healthy controls. Revised model criteria led to a healthy range of 19 U/L in women and 30 U/L in men. This led to a 21.3% increase in sensitivity for an 8.9% decrease in specificity. References1. ^{{cite journal |last1=Prati |first1=Daniele |last2=Taioli |first2=Emanuela |last3=Zanella |first3=Alberto |last4=Della Torre |first4=Emanuela |last5=Butelli |first5=Sonia |last6=Del Vecchio |first6=Emanuela |last7=Vianello |first7=Luciana |last8=Zanuso |first8=Francesco |last9=Mozzi |first9=Fulvio |last10=Milani |first10=Silvano |last11=Conte |first11=Dario |last12=Colombo |first12=Massimo |last13=Sirchia |first13=Girolamo |title=Updated Definitions of Healthy Ranges for Serum Alanine Aminotransferase Levels |journal=Ann Intern Med |year=2002 |volume=137 |pages=1–9 |doi=10.7326/0003-4819-137-1-200207020-00006}} {{Med-diagnostic-stub}} 2 : Medical diagnosis|Liver |
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