| 词条 | PRO 2000 |
| 释义 |
| drug_name = | IUPAC_name = Sodium 2-naphthalenesulfonate, polymer with formaldehyde | image = | alt = | caption = | CAS_number = 29321-75-3 | ATCvet = | ATC_prefix = | ATC_suffix = | PubChem = | DrugBank = | ChemSpiderID = none | NIAID_ChemDB = 032942 | synonyms = 2-Naphthalenesulfonic acid, sodium salt, polymer with formaldehyde | chemical_formula = (C10H8O3S.CH2O.Na)x | molecular_weight = Approximately 5 kg/mol }} PRO 2000 is an experimental vaginal microbicide which has been proposed as a preventative medicine for reducing the risk of contracting HIV. It has never been recommended as an effective medicine to be used for any purpose. Some clinical trials have shown that under some conditions it may provide some protection against HIV. HistoryEndo Pharmaceuticals manufactures the drug.[1]EfficacyAnimal testing studies done on macaques have shown that PRO 2000 is effective in preventing the transmission of HIV. Other studies have given supportive evidence that the product is safe in humans and would be an appropriate candidate for testing.[2]A phase III clinical trial of 9385 women in sub-Saharan Africa showed that PRO 2000 was not effective in preventing transmission of HIV.[3] References1. ^{{cite web|url=http://www.aidsinfo.nih.gov/DrugsNew/DrugDetailNT.aspx?int_id=330 |title=AIDSinfo - HIV/AIDS Drug Information - PRO 2000 |first= |last= |work=aidsinfo.nih.gov |year=2011 |accessdate=20 November 2011 |deadurl=yes |archiveurl=https://web.archive.org/web/20111017205642/http://aidsinfo.nih.gov/DrugsNew/DrugDetailNT.aspx?int_id=330 |archivedate=October 17, 2011 }} {{Microbicides for sexually transmitted diseases}}2. ^{{Cite journal | last1 = Patton | first1 = D. L. | last2 = Cosgrove Sweeney | first2 = Y. T. | last3 = Paul | first3 = K. J. | doi = 10.1097/OLQ.0b013e31817dfdb8 | title = A Summary of Preclinical Topical Microbicide Vaginal Safety and Chlamydial Efficacy Evaluations in a Pigtailed Macaque Model | journal = Sexually Transmitted Diseases | volume = 35 | issue = 10 | pages = 889–897 | year = 2008 | pmid = 18607310| pmc = }} 3. ^{{Cite journal | last1 = McCormack | first1 = S. | last2 = Ramjee | first2 = G. | last3 = Kamali | first3 = A. | last4 = Rees | first4 = H. | last5 = Crook | first5 = A. M. | last6 = Gafos | first6 = M. | last7 = Jentsch | first7 = U. | last8 = Pool | first8 = R. | last9 = Chisembele | first9 = M. | last10 = Kapiga | first10 = S. | last11 = Mutemwa | first11 = R. | last12 = Vallely | first12 = A. | last13 = Palanee | first13 = T. | last14 = Sookrajh | first14 = Y. | last15 = Lacey | first15 = C. J. | last16 = Darbyshire | first16 = J. | last17 = Grosskurth | first17 = H. | last18 = Profy | first18 = A. | last19 = Nunn | first19 = A. | last20 = Hayes | first20 = R. | last21 = Weber | first21 = J. | title = PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): A phase 3, randomised, double-blind, parallel-group trial | journal = The Lancet | volume = 376 | issue = 9749 | pages = 1329–37 | year = 2010 | doi = 10.1016/S0140-6736(10)61086-0 | pmid=20851460 | pmc=2956883}} 1 : Microbicides |
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