| 词条 | Proenkephalin |
| 释义 |
| Name = Proenkephalin | image = | width = | caption = | Symbol = PENK | AltSymbols = | IUPHAR_id = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | CAS_number = 90880-95-8 | CAS_supplemental = | DrugBank = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | UniProt = | ECnumber = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}Proenkephalin (PENK), formerly known as proenkephalin A (since proenkephalin B was renamed prodynorphin), is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides [Met]enkephalin, and to a lesser extent, [Leu]enkephalin.[1] Upon cleavage, each proenkephalin peptide results in the generation of four copies of [Met]enkephalin, two extended copies of [Met]enkephalin, and one copy of [Leu]enkephalin.[1] Contrarily, [Leu]enkephalin] is predominantly synthesized from prodynorphin, which produces three copies of it per cleavage, and no copies of [Met]enkephalin. Other endogenous opioid peptides produced by proenkephalin include adrenorphin,[2] amidorphin,[3] BAM-18,[4] BAM-20P,[5] BAM-22P,[5] peptide B,[6] peptide E,[7] and peptide F.[8] See also{{Portal|Neuroscience}}
References1. ^1 {{cite book | author = Donald W. Pfaff | title = Hormones, brain, and behavior | url = https://books.google.com/books?id=cGbE2nC__Q0C&pg=PA173 | accessdate = 25 November 2011 | year = 2002 | publisher = Elsevier | isbn = 978-0-12-532109-9 | pages = 173}} 2. ^{{cite journal |vauthors=Matsuo H, Miyata A, Mizuno K | title = Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour | journal = Nature | volume = 305 | issue = 5936 | pages = 721–3 | year = 1983 | pmid = 6633641 | doi = 10.1038/305721a0| url = }} 3. ^{{cite journal |vauthors=Seizinger BR, Liebisch DC, Gramsch C, etal | title = Isolation and structure of a novel C-terminally amidated opioid peptide, amidorphin, from bovine adrenal medulla | journal = Nature | volume = 313 | issue = 5997 | pages = 57–9 | year = 1985 | pmid = 3965972 | doi = 10.1038/313057a0| url = }} 4. ^{{cite journal |vauthors=Hurlbut DE, Evans CJ, Barchas JD, Leslie FM | title = Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18 | journal = European Journal of Pharmacology | volume = 138 | issue = 3 | pages = 359–66 |date=June 1987 | pmid = 3040439 | doi = 10.1016/0014-2999(87)90474-2| url = }} 5. ^1 {{cite journal |vauthors=Mizuno K, Minamino N, Kangawa K, Matsuo H | title = A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity | journal = Biochemical and Biophysical Research Communications | volume = 97 | issue = 4 | pages = 1283–90 |date=December 1980 | pmid = 7213356 | doi = 10.1016/S0006-291X(80)80005-2| url = http://linkinghub.elsevier.com/retrieve/pii/S0006-291X(80)80005-2}} 6. ^{{cite journal |vauthors=Micanovic R, Kruggel W, Ray P, Lewis RV | title = Purification and sequence of a non-opioid peptide derived from ovine proenkephalin: implications for possible species specific processing | journal = Peptides | volume = 5 | issue = 5 | pages = 853–6 | year = 1984 | pmid = 6504720 | doi = 10.1016/0196-9781(84)90105-0| url = }} 7. ^{{cite journal |vauthors=Boarder MR, Evans C, Adams M, Erdelyi E, Barchas JD | title = Peptide E and its products, BAM 18 and Leu-enkephalin, in bovine adrenal medulla and cultured chromaffin cells: release in response to stimulation | journal = Journal of Neurochemistry | volume = 49 | issue = 6 | pages = 1824–32 |date=December 1987 | pmid = 3681299 | doi = 10.1111/j.1471-4159.1987.tb02443.x| url = }} 8. ^{{cite journal |vauthors=Jones BN, Stern AS, Lewis RV, etal | title = Structure of two adrenal polypeptides containing multiple enkephalin sequences | journal = Archives of Biochemistry and Biophysics | volume = 204 | issue = 1 | pages = 392–5 |date=October 1980 | pmid = 7425644 | doi = 10.1016/0003-9861(80)90048-X| url = http://linkinghub.elsevier.com/retrieve/pii/0003-9861(80)90048-X}} External links
3 : Opioids|Neuropeptides|Precursor proteins |
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