“Protein-fructosamine 3-kinase”的意思、由来-开放百科全书

词条

Protein-fructosamine 3-kinase

释义

References
External links

{{Infobox enzyme
| Name = Protein-fructosamine 3-kinase
| EC_number = 2.7.1.171
| CAS_number =
| IUBMB_EC_number = 2/7/1/171
| GO_code =
| image =
| width =
| caption =
}}Protein-fructosamine 3-kinase ({{EC number|2.7.1.171}}, FN3K, fructosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N⁶-D-fructosyl-L-lysine 3-phosphotransferase.^[1]^[2] This enzyme catalyses the following chemical reaction

ATP + [protein]-N⁶-D-fructosyl-L-lysine ADP + [protein]-N⁶-(3-O-phospho-D-fructosyl)-L-lysine

Nonenzymatic glycation is a factor in the pathogenesis of diabetes.

References

1. ^{{cite journal | vauthors = Szwergold BS, Howell S, Beisswenger PJ | title = Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo | journal = Diabetes | volume = 50 | issue = 9 | pages = 2139–47 | date = September 2001 | pmid = 11522682 | doi = 10.2337/diabetes.50.9.2139 }}
2. ^{{cite journal | vauthors = Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E | title = Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase | journal = Diabetes | volume = 49 | issue = 10 | pages = 1627–34 | date = October 2000 | pmid = 11016445 | doi = 10.2337/diabetes.49.10.1627 }}

External links

{{MeshName|Protein-fructosamine+3-kinase}}

1 : EC 2.7.1

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