| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.[1] Function This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]. References 1. ^{{cite web | title = Entrez Gene: Protease, serine, 2 (trypsin 2) | url = https://www.ncbi.nlm.nih.gov/gene/5645 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Williams SJ, Gotley DC, Antalis TM | title = Human trypsinogen in colorectal cancer | journal = International Journal of Cancer | volume = 93 | issue = 1 | pages = 67–73 | date = July 2001 | pmid = 11391623 | pmc = | doi = 10.1002/ijc.1304 }}
- {{cite journal | vauthors = Mayumi T, Inui K, Maetani I, Yokoe M, Sakamoto T, Yoshida M, Ko S, Hirata K, Takada T | title = Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis | journal = Pancreas | volume = 41 | issue = 6 | pages = 869–75 | date = August 2012 | pmid = 22481290 | pmc = | doi = 10.1097/MPA.0b013e3182480ab7 | author10 = Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP Study Group) }}
- {{cite journal | vauthors = | title = PRSS1-Related Hereditary Pancreatitis | year = 1993 | pmid = 22379635 }}
- {{cite journal | vauthors = Ahmed M, Forsberg J, Bergsten P | title = Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry | journal = Journal of Proteome Research | volume = 4 | issue = 3 | pages = 931–40 | year = 2005 | pmid = 15952740 | pmc = | doi = 10.1021/pr050024a }}
- {{cite journal | vauthors = Vilen ST, Suojanen J, Salas F, Risteli J, Ylipalosaari M, Itkonen O, Koistinen H, Baumann M, Stenman UH, Sorsa T, Salo T, Nyberg P | title = Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating ProMT1-MMP | journal = Cancer Investigation | volume = 30 | issue = 8 | pages = 583–92 | date = October 2012 | pmid = 22909050 | pmc = | doi = 10.3109/07357907.2012.716467 }}
- {{cite journal | vauthors = Lempinen M, Isoniemi H, Mäkisalo H, Nordin A, Halme L, Arola J, Höckerstedt K, Stenman UH | title = Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures | journal = Journal of Hepatology | volume = 47 | issue = 5 | pages = 677–83 | date = November 2007 | pmid = 17640760 | pmc = | doi = 10.1016/j.jhep.2007.05.017 }}
- {{cite journal | vauthors = Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A | title = Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes | journal = Journal of Neurovirology | volume = 9 | issue = 3 | pages = 358–71 | date = June 2003 | pmid = 12775419 | pmc = | doi = 10.1080/13550280390201119 }}
- {{cite journal | vauthors = Baptista AM, Jonson PH, Hough E, Petersen SB | title = The origin of trypsin: evidence for multiple gene duplications in trypsins | journal = Journal of Molecular Evolution | volume = 47 | issue = 3 | pages = 353–62 | date = September 1998 | pmid = 9732462 | doi = 10.1007/PL00006393 }}
- {{cite journal | vauthors = Gao J, Zhu F, Lv S, Li Z, Ling Z, Gong Y, Jie C, Ma L | title = Identification of pancreatic juice proteins as biomarkers of pancreatic cancer | journal = Oncology Reports | volume = 23 | issue = 6 | pages = 1683–92 | date = June 2010 | pmid = 20428826 | doi = 10.3892/or_00000812 }}
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