| 词条 | PSB-SB-1202 |
| 释义 |
| IUPAC_name = 7-pentyl-5-methoxy-3-(2-methoxybenzyl)-2H-chromen-2-one | image = PSB-SB-1202_structure.png | width = 280 | tradename = | CAS_number = 1399049-60-5 | PubChem = 70677953 | ChemSpiderID = 28668367 | C=23 | H=26 | O=4 | molecular_weight = 366.45 | smiles = O=C1C(CC2=C(OC)C=CC=C2)=CC3=C(C=C(CCCCC)C=C3OC)O1 | StdInChI = 1S/C23H26O4/c1-4-5-6-9-16-12-21(26-3)19-15-18(23(24)27-22(19)13-16)14-17-10-7-8-11-20(17)25-2/h7-8,10-13,15H,4-6,9,14H2,1-3H3 | StdInChIKey = VZYCAUIYIZSPQY-UHFFFAOYSA-N }}PSB-SB-1202 is a coumarin derivative which is an agonist at the cannabinoid receptors CB1 and CB2, with a CB1 Ki of 32nM and a CB2 Ki of 49nM.[1] It is also a weak antagonist at the related receptor GPR55, with an IC50 of 6350nM, but has no significant affinity for GPR18.[2] See also
References1. ^Rempel V, Volz N, Hinz S, Karcz T, Meliciani I, Nieger M, Wenzel W, Bräse S, Müller CE. 7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists. Journal of Medicinal Chemistry. 2012 Sep 27;55(18):7967-77. {{PMID|22916707}} {{Cannabinoids}}2. ^{{Cite journal | last1 = Rempel | first1 = V. | last2 = Volz | first2 = N. | last3 = Gläser | first3 = F. | last4 = Nieger | first4 = M. | last5 = Bräse | first5 = S. | last6 = Müller | first6 = C. E. | title = Antagonists for the orphan G protein-coupled receptor GPR55 based on a coumarin scaffold | doi = 10.1021/jm4005175 | journal = Journal of Medicinal Chemistry | pages = 130516144836005 | year = 2013 | pmid = 23679955 | pmc = | volume=56 | issue=11}} 1 : Cannabinoids |
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