| 词条 | Pseudomonalisin |
| 释义 |
| Name = Sedolisin | EC_number = 3.4.21.100 | CAS_number = 848318-58-1 | IUBMB_EC_number = 3/4/21/100 | GO_code = | image = | width = | caption = }}Sedolisin ({{EC number|3.4.21.100}}, Pseudomonas sp. pepstatin-insensitive carboxyl proteinase, pseudomonapepsin, sedolysin) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction Hydrolysis of the B chain of insulin at -Glu13-Ala-, -Leu15-Tyr- and -Phe25-Tyr-, and angiotensin I at -Tyr4-Ile-. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu. This enzyme is secreted by Pseudomonas sp. No. 101. References1. ^{{cite journal | vauthors = Oda K, Sugitani M, Fukuhara K, Murao S | title = Purification and properties of a pepstatin-insensitive carboxyl proteinase from a gram-negative bacterium | journal = Biochimica et Biophysica Acta | volume = 923 | issue = 3 | pages = 463–9 | date = March 1987 | pmid = 3548827 | doi = 10.1016/0304-4165(87)90055-9 }} 2. ^{{cite journal | vauthors = Oda K, Nakatani H, Dunn BM | title = Substrate specificity and kinetic properties of pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. No. 101 | journal = Biochimica et Biophysica Acta | volume = 1120 | issue = 2 | pages = 208–14 | date = April 1992 | pmid = 1562589 | doi = 10.1016/0167-4838(92)90272-f }} 3. ^{{cite journal | vauthors = Wlodawer A, Li M, Dauter Z, Gustchina A, Uchida K, Oyama H, Dunn BM, Oda K | title = Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes | journal = Nature Structural Biology | volume = 8 | issue = 5 | pages = 442–6 | date = May 2001 | pmid = 11323721 | doi = 10.1038/87610 }} 4. ^{{cite journal | vauthors = Wlodawer A, Li M, Gustchina A, Oyama H, Dunn BM, Oda K | title = Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases | url = http://www.actabp.pl/pdf/1_2003/81.pdf | journal = Acta Biochimica Polonica | volume = 50 | issue = 1 | pages = 81–102 | date = 2003 | pmid = 12673349 }} External links
1 : EC 3.4.21 |
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