“Ptc1”的意思、由来-开放百科全书

词条

Ptc1

释义

Biological Processes
References

Ptc1 is a type Two C phosphatase ^[1] involved in the mating decision of yeast. Ptc1 competes with Fus3 for control of the 4 phosphorylation sites on the scaffold protein Ste5. Presence of the mating pheromone α-factor causes Ptc1 to be recruited to Ste5. This recruitment takes place via a 4 amino acid motif in the Ste5 phosphosites.^[2]

Ptc1 is also involved in regulating the osmotic stress of yeast, especially via inactivation of Hog1, a member of the MAPK pathway. This inactivation occurred as a result of dephosphorylation of the phosphotheronine but not the phosphotyrosine residue in the phosphorylation lip of Hog1.^[3]

It can be localized to the cytoplasm and nucleus.^[1]

Biological Processes

Ptc1 is involved in the following biological processes:^[1]

Inactivation of MAPK activity in osmosensory signalling pathways
Mitochondrial inheritance
Pheromone-dependent signal transduction in conjugation with cellular fusion
Protein dephosphorylation
tRNA splicing via. Endonucleolytic cleavage and ligation

References

1 : Enzymes of known structure

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