Punyamurthula is an Indian surname. Notable people with the name include:

• Ananth Babu (born Punyamurthula Ananth), Indian film actor and comedian
• Chitti Babu (Telugu actor) (born Punyamurthula Suryanarayana Murthy), Indian film actor and comedian
• Raja Babu (actor) (born Punyamurthula Appalaraju; 1937–1983), Indian film actor and comedian

• Lesser hairy-winged bat
• Lesser Hampden
• Lesser Hamster-rat
• Lesser hamster-rat
• Lesser hedgehog tenrec
• Lesser Himalaya
• Lesser Himalayas
• Lesser himalayas
• Lesser Hippias
• Lesser honeyguide
• Lesser Hoopoe Lark
• Lesser hoopoe-lark
• Lesser horn
• Lesser horned owl
• Lesser hornero
• Lesser Horseshoe-Bat
• Lesser housefly
• Lesser house fly
• Lesser house spider
• Lesser included charge
• Lesser iron-gray dwarf lemur
• Lesser jacana
• Lesser Jay
• Lesser Jihad
• Lesser kiskadee