| 词条 | PX-3 |
| 释义 |
| IUPAC_name = N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-1-(cyclohexylmethyl)indazole-3-carboxamide | image = APP-CHMINACA.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule II | legal_UK = | legal_US = | legal_status = Illegal in Sweden | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 1185887-14-2 | ATC_prefix = | ATC_suffix = | PubChem = 44206137 | ChemSpiderID = 48063640 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 3877T06H05 | smiles = NC(=O)[C@H](Cc1ccccc1)NC(=O)c2nn(CC3CCCCC3)c4ccccc24 | StdInChI = 1S/C24H28N4O2/c25-23(29)20(15-17-9-3-1-4-10-17)26-24(30)22-19-13-7-8-14-21(19)28(27-22)16-18-11-5-2-6-12-18/h1,3-4,7-10,13-14,18,20H,2,5-6,11-12,15-16H2,(H2,25,29)(H,26,30)/t20-/m0/s1 | StdInChIKey = DMHWDSGURMXMGE-FQEVSTJZSA-N | C=24 | H=28 | N=4 | O=2 | molecular_weight = 404.5 g/mol }}PX-3 (also known as APP-CHMINACA) is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a binding affinity of Ki = 47.6 nM and was originally developed by Pfizer in 2009 as an analgesic medication.[1][2][3] The acronym 'APP' signifies the 'amino', 'phenyl' and 'propanone' elements of the structure. Three related compounds, PX-1 (5F-APP-PICA, SRF-30), PX-2 (5F-APP-PINACA, FU-PX) and APP-FUBINACA were reported by the EMCDDA in late 2014.[4][5] LegalitySweden's public health agency suggested to classify APP-CHMINACA as hazardous substance on June 1, 2015.[6] See also{{div col|colwidth=30em}}
References1. ^{{cite web | url=https://www.caymanchem.com/app/template/Product.vm/catalog/17614 | title=APP-CHMINACA | publisher=Cayman Chemical | accessdate=24 June 2015}} {{Cannabinoids}}{{Cannabinoidergics}}{{cannabinoid-stub}}2. ^{{cite journal | url=https://www.google.com/patents/WO2009106980A3 | title=Patent WO/2009/106980 - Indazole derivatives}} 3. ^{{cite web | url=https://forum.goeg.at/EwsForum/default.aspx?g=posts&t=211 | title=EWS Forum - In Belgien wurde die neue psychoaktive Substanz N-(2-amino-1-benzyl-2-oxo-ethyl)-1-(cyclohexylmethyl)indazole-3-carboxamide (APP-CHMINACA) identifiziert. | accessdate=24 June 2015}} 4. ^{{cite web | url=https://forum.goeg.at/EwsForum/default.aspx?g=posts&t=194 | title=EWS Forum - In Schweden wurde die neue psychoaktive Substanz N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (5F-APP-PICA) identifiziert. | accessdate=24 June 2015}} 5. ^{{cite web | url=https://forum.goeg.at/EwsForum/default.aspx?g=posts&t=193 | title=EWS Forum - In Schweden wurden folgende drei neue psychoaktive Substanzen identifiziert. | accessdate=24 June 2015}} 6. ^{{cite web | url=http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2015/juni/23-nya-amnen-kan-klassas-som-narkotika-eller-halsofarlig-vara | title=23 nya ämnen kan klassas som narkotika eller hälsofarlig vara | publisher=Folkhälsomyndigheten | accessdate=29 June 2015}} 4 : Indazoles|Cannabinoids|Designer drugs|Indazolecarboxamides |
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