Quaker City could refer to:

• Quaker City, Ohio, a city in eastern Ohio
• USS Quaker City (1854), featured in Mark Twain's novel The Innocents Aboard
• a nickname for Philadelphia, Pennsylvania
• a train operated by Amtrak as part of the Clocker service
• The Quaker City, or The Monks of Monk Hall, a novel by George Lippard

• Minnesota State University
• Minnesota State University-Mankato
• Minnesota State University, Mankato
• Minnesota State University Moorhead
• Minnesota Strikers
• Minnesota study of twins reared apart
• Minnesota Supreme Court
• Minnesota Swarm
• Minnesota Territory
• Minnesota Thunder
• Minnesota Timberwolves
• Minnesota Transportation Museum
• Minnesota Transracial Adoption Study
• Minnesota Twin Family Study
• Minnesota Twin Registry
• Minnesota Twins
• Minnesota Twins award winners and league leaders
• Minnesota Twins Study
• Minnesota, United States
• Minnesota Valley Canning Company
• Minnesota Viking
• Minnesota Vikings
• Minnesota whist
• Minnesota Wild
• Minnesota Zen Meditation Center