| 词条 | Quilizumab |
| 释义 |
| type = mab | image = | alt = | mab_type = mab | source = zu/o | target = IGHE | ChemSpiderID = none | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 1228538-47-3 | ATC_prefix = none | ATC_suffix = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 26F96HRJ3W | PubChem = | DrugBank = | KEGG = D10409 | C=6492 | H=10046 | N=1728 | O=2023 | S=44 | molecular_weight = 146.1 kg/mol }}Quilizumab (INN) is a humanized monoclonal antibody designed for the treatment of asthma.[1] It binds to IGHE.[2][3][4][5][6][7] This drug was developed by Genentech. References1. ^Statement On A Nonproprietary Name Adopted By The USAN Council - Quilizumab, American Medical Association. {{monoclonals for immune system}}{{monoclonal-antibody-stub}}2. ^{{cite journal | author = World Health Organization | title = International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 106 | journal = WHO Drug Information | volume = 25 | issue = 4 | year = 2011 | url = http://www.who.int/medicines/publications/druginformation/innlists/Final_PL106.pdf | format=PDF}} 3. ^{{cite journal |vauthors=Harris JM, Cabanski CR, Scheerens H, Samineni D, Bradley MS, Cochran C, Staubach P, Metz M, Sussman G, Maurer M |title=A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria |journal=J. Allergy Clin. Immunol. |volume=138 |issue=6 |pages=1730–1732 |date=December 2016 |pmid=27567329 |doi=10.1016/j.jaci.2016.06.023 |url=}} 4. ^{{cite journal |vauthors=Harris JM, Maciuca R, Bradley MS, Cabanski CR, Scheerens H, Lim J, Cai F, Kishnani M, Liao XC, Samineni D, Zhu R, Cochran C, Soong W, Diaz JD, Perin P, Tsukayama M, Dimov D, Agache I, Kelsen SG |title=A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma |journal=Respir. Res. |volume=17 |issue= |pages=29 |date=March 2016 |pmid=26993628 |pmc=4797126 |doi=10.1186/s12931-016-0347-2 |url=}} 5. ^{{cite journal |vauthors=Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM |title=Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production |journal=Sci Transl Med |volume=6 |issue=243 |pages=243ra85 |date=July 2014 |pmid=24990880 |doi=10.1126/scitranslmed.3008961 |url=}} 6. ^{{cite journal |vauthors=Licari A, Castagnoli R, Panfili E, Marseglia A, Brambilla I, Marseglia GL |title=An Update on Anti-IgE Therapy in Pediatric Respiratory Diseases |journal=Curr Respir Med Rev |volume=13 |issue=1 |pages=22–29 |date=March 2017 |pmid=29290750 |pmc=5735517 |doi=10.2174/1573398X13666170616110738 |url=}} 7. ^{{cite journal |vauthors=Deza G, Ricketti PA, Giménez-Arnau AM, Casale TB |title=Emerging Biomarkers and Therapeutic Pipelines for Chronic Spontaneous Urticaria |journal=J Allergy Clin Immunol Pract |volume=6 |issue=4 |pages=1108–1117 |date=2018 |pmid=30033912 |doi=10.1016/j.jaip.2018.02.024 |url=}} 1 : Monoclonal antibodies |
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