R353 road may refer to:

• R353 road (Ireland)
• R353 road (South Africa)

• Pontiac automobile
• Pontiac (automobile)
• Pontiac Banshee
• Pontiac Bonneville Safari
• Pontiac Bonneville Special
• Pontiac Can Am
• Pontiac Catalina Safari
• Pontiac Central High School
• Pontiac Chieftain
• Pontiac club de mer
• Pontiac Club de Mer
• Pontiac Correctional Center
• Pontiac Custom S
• Pontiac East Assembly
• Pontiac Excitement 400
• Pontiac Executive
• Pontiac G2
• Pontiac G3
• Pontiac G4
• Pontiac G5
• Pontiac G5 Pursuit
• Pontiac G8
• Pontiac-Gatineau-Labelle
• Pontiac Grand AM
• Pontiac Grande Parisienne