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词条 RAB7L1
释义

  1. Model organisms

  2. References

  3. Further reading

RAB7, member RAS oncogene family-like 1 is a protein that in humans is encoded by the RAB7L1 gene.[1] The gene is also known as RAB7L. RAB7L1 encodes a small GTP-binding protein and is a member of the Ras superfamily.[1][2]

Model organisms

Model organisms have been used in the study of RAB7L1 function. A conditional knockout mouse line, called Rab7l1tm1a(EUCOMM)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty one tests were carried out on mutant mice, but no significant abnormalities were observed.[4]

References

1. ^{{cite web | title = RAB7, member RAS oncogene family-like 1| url = https://www.ncbi.nlm.nih.gov/gene/8934| accessdate = 2011-12-06}}
2. ^{{Cite journal | doi = 10.1159/000134591 | last1 = Shimizu | first1 = F. | last2 = Katagiri | first2 = T. | last3 = Suzuki | first3 = M. | last4 = Watanabe | first4 = T. K. | last5 = Okuno | first5 = S. | last6 = Kuga | first6 = Y. | last7 = Nagata | first7 = M. | last8 = Fujiwara | first8 = T. | last9 = Nakamura | first9 = Y. | last10 = Takahashi | first10 = E. | title = Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily | journal = Cytogenetics and Cell Genetics | volume = 77 | issue = 3–4 | pages = 261–263 | year = 1997 | pmid = 9284931}}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MCSP/citrobacter-challenge/ |title=Citrobacter infection data for Rab7l1 |publisher=Wellcome Trust Sanger Institute}}
4. ^{{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
5. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
6. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Rab7l1 |title=International Knockout Mouse Consortium}}
7. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432353 |title=Mouse Genome Informatics}}
8. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }}
9. ^{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |journal=Nature |volume=474 |issue=7351 |pages=262–3 |date=June 2011 |pmid=21677718 |doi=10.1038/474262a }}
10. ^{{cite journal |vauthors=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |date=January 2007 |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}
11. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}}

Further reading

  • {{Cite journal

| last1 = Tucci | first1 = A.
| last2 = Nalls | first2 = M. A.
| last3 = Houlden | first3 = H.
| last4 = Revesz | first4 = T.
| last5 = Singleton | first5 = A. B.
| last6 = Wood | first6 = N. W.
| last7 = Hardy | first7 = J.
| last8 = Paisán-Ruiz | first8 = C.
| doi = 10.1038/ejhg.2010.125
| title = Genetic variability at the PARK16 locus
| journal = European Journal of Human Genetics
| volume = 18
| issue = 12
| pages = 1356–1359
| year = 2010
| pmid = 20683486
| pmc =3002857
}}{{refend}}{{gene-1-stub}}

2 : Human proteins|Genes mutated in mice

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