| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Rhomboid, veinlet-like 2 (Drosophila) is a protein that in humans is encoded by the RHBDL2 gene.[1] Function The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. References 1. ^{{cite web | title = Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila) | url = https://www.ncbi.nlm.nih.gov/gene/54933 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M | title = Mammalian EGF receptor activation by the rhomboid protease RHBDL2 | journal = EMBO Reports | volume = 12 | issue = 5 | pages = 421–7 | date = May 2011 | pmid = 21494248 | pmc = 3090019 | doi = 10.1038/embor.2011.50 }}
- {{cite journal | vauthors = Pascall JC, Brown KD | title = Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2 | journal = Biochemical and Biophysical Research Communications | volume = 317 | issue = 1 | pages = 244–52 | date = April 2004 | pmid = 15047175 | doi = 10.1016/j.bbrc.2004.03.039 }}
- {{cite journal | vauthors = Cheng TL, Wu YT, Lin HY, Hsu FC, Liu SK, Chang BI, Chen WS, Lai CH, Shi GY, Wu HL | title = Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing | journal = The Journal of Investigative Dermatology | volume = 131 | issue = 12 | pages = 2486–94 | date = December 2011 | pmid = 21833011 | doi = 10.1038/jid.2011.230 }}
- {{cite journal | vauthors = Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, Kader AK, Li G, Purcell LD, Kim ST, Hsu FC, Stattin P, Hugosson J, Adolfsson J, Walsh PC, Trent JM, Duggan D, Carpten J, Grönberg H, Isaacs WB | title = Inherited genetic variant predisposes to aggressive but not indolent prostate cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 107 | issue = 5 | pages = 2136–40 | date = February 2010 | pmid = 20080650 | pmc = 2836698 | doi = 10.1073/pnas.0914061107 }}
- {{cite journal | vauthors = Urban S, Freeman M | title = Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain | journal = Molecular Cell | volume = 11 | issue = 6 | pages = 1425–34 | date = June 2003 | pmid = 12820957 | doi = 10.1016/s1097-2765(03)00181-3 }}
- {{cite journal | vauthors = Urban S, Lee JR, Freeman M | title = Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases | journal = Cell | volume = 107 | issue = 2 | pages = 173–82 | date = October 2001 | pmid = 11672525 | doi = 10.1016/s0092-8674(01)00525-6 }}
- {{cite journal | vauthors = Lei X, Li YM | title = The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity | journal = Journal of Molecular Biology | volume = 394 | issue = 5 | pages = 815–25 | date = December 2009 | pmid = 19850051 | doi = 10.1016/j.jmb.2009.10.025 }}
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