| 词条 | Ritalinic acid |
| 释义 |
| Watchedfields = changed | verifiedrevid = 464371569 | IUPAC_name = Phenyl(piperidin-2-yl)acetic acid | image = Ritalinic acid-2D-skeletal.svg | legal_US = Unscheduled | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 19395-41-6 | PubChem = 86863 | ATC_prefix = None | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 78360 | C=13 | H=17 | N=1 | O=2 | molecular_weight = 219.28 g/mol | smiles = C1CCNC(C1)C(C2=CC=CC=C2)C(=O)O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = InChI=1S/C13H17NO2/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = INGSNVSERUZOAK-UHFFFAOYSA-N }}Ritalinic acid is a substituted phenethylamine and an inactive major metabolite of the psychostimulant drugs methylphenidate and ethylphenidate.[1][2] When administered orally, methylphenidate is extensively metabolized in the liver by hydrolysis of the ester group yielding ritalinic acid.[1] The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1).[3] UsesRitalinic acid is used as an intermediate in the synthesis of methylphenidate and its analogues, such as ethylphenidate and isopropylphenidate. References1. ^1 {{Cite journal | pmid = 4473537| year = 1974| author1 = Faraj| first1 = B. A.| title = Metabolism and disposition of methylphenidate-14C: Studies in man and animals| journal = The Journal of Pharmacology and Experimental Therapeutics| volume = 191| issue = 3| pages = 535–47| last2 = Israili| first2 = Z. H.| last3 = Perel| first3 = J. M.| last4 = Jenkins| first4 = M. L.| last5 = Holtzman| first5 = S. G.| last6 = Cucinell| first6 = S. A.| last7 = Dayton| first7 = P. G.}} 2. ^{{cite journal | url=http://www.sciencedirect.com/science/article/pii/S0731708515301709 | title=Identification of in vitro metabolites of ethylphenidate by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry |author1=Noelia Negreira |author2=Claudio Erratico |author3=Alexander L.N. van Nuijs |author4=Adrian Covaci | journal=Journal of Pharmaceutical and Biomedical Analysis | date=January 2016 | volume=117 | issue=5 | pages=474–484 | doi=10.1016/j.jpba.2015.09.029 | pmid=26454340}} 3. ^{{Cite journal| last1 = Sun | first1 = Z.| last2 = Murry | first2 = D.| last3 = Sanghani | first3 = S.| last4 = Davis | first4 = W.| last5 = Kedishvili | first5 = N.| last6 = Zou | first6 = Q.| last7 = Hurley | first7 = T.| last8 = Bosron | first8 = W.| title = Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1| journal = The Journal of Pharmacology and Experimental Therapeutics| volume = 310| issue = 2| pages = 469–476| year = 2004| pmid = 15082749| doi = 10.1124/jpet.104.067116}} 2 : Piperidines|Methylphenidate |
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