| 词条 | SARS coronavirus main proteinase |
| 释义 |
| Name = SARS coronavirus main proteinase | EC_number = 3.4.22.69 | CAS_number = | IUBMB_EC_number = 3/4/22/69 | GO_code = | image = 3iwm.jpg | width = 270 | caption = SARS main proteinase oktamer }}SARS coronavirus main proteinase ({{EC number|3.4.22.69}}, 3cLpro, 3C-like protease, coronavirus 3C-like protease, Mpro, SARS 3C-like protease, SARS coronavirus 3CL protease, SARS coronavirus main peptidase, SARS coronavirus main protease, SARS-CoV 3CLpro enzyme, SARS-CoV main protease, SARS-CoV Mpro, severe acute respiratory syndrome coronavirus main protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction{{quote|TSAVLQ-SGFRK-NH2 and SGVTFQ-!GKFKK are the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase}} This protease is important in SARS coronavirus replicase polyprotein processing. References1. ^{{cite journal | vauthors = Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS | title = Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus | journal = Biochemistry | volume = 46 | issue = 30 | pages = 8744–52 | date = July 2007 | pmid = 17605471 | doi = 10.1021/bi0621415 }} 2. ^{{cite journal | vauthors = Fan K, Wei P, Feng Q, Chen S, Huang C, Ma L, Lai B, Pei J, Liu Y, Chen J, Lai L | title = Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 3 | pages = 1637–42 | date = January 2004 | pmid = 14561748 | doi = 10.1074/jbc.m310875200 }} 3. ^{{cite journal | vauthors = Akaji K, Konno H, Onozuka M, Makino A, Saito H, Nosaka K | title = Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant | journal = Bioorganic & Medicinal Chemistry | volume = 16 | issue = 21 | pages = 9400–8 | date = November 2008 | pmid = 18845442 | doi = 10.1016/j.bmc.2008.09.057 }} External links
2 : EC 3.4.22|Betacoronaviruses |
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