| 词条 | Sequential high-dose chemotherapy | |||||||||||||||||||||||||
| 释义 |
| name = Sequential high-dose chemotherapy | synonym = | image = | caption = | alt = | pronounce = | specialty = oncology | synonyms = | ICD10 = | ICD9 = | ICD9unlinked = | CPT = | MeshID = | LOINC = | other_codes = | MedlinePlus = | eMedicine = }}Sequential high-dose chemotherapy is a chemotherapy regimen consisting of several (2 to 4) sequential monochemotherapies with only one chemotherapeutic agent per course. The idea behind this approach is that when using single-agent chemotherapy, the doctor can easily escalate the dose of the drug to the maximum tolerable dose by the patient, avoiding additive hematological toxicity from chemotherapeutic combinations, and thus improving efficacy. It is mostly used as consolidation therapy for relapsed or refractory lymphomas and relapsed or refractory Hodgkin disease, after DHAP induction.[1][2] There is also an ongoing trial of this approach in multiple myeloma.[3] Dosing regimen
Depending on the patient's performance status, his/her ability to tolerate chemotherapy, the type of lymphoma, the stage of disease and different prognostic factors, one or more courses of the full sequence can be omitted or dose reduced. After completion of the sequence, the patient will usually undergo pre-transplant conditioning chemotherapy regimen (such as BEAM) and then will get autologous stem cell transplantation as the final consolidation. References1. ^{{cite journal| pmid=16966265 | doi=10.1080/10428190600570958 | volume=47 | title=High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma | year=2006 | author=Oyan B, Koc Y, Ozdemir E, Kars A, Turker A, Tekuzman G, Kansu E | journal=Leuk Lymphoma | pages=1545–52}} 2. ^{{cite journal| pmid=15598948 | doi=10.1093/annonc/mdi003 | volume=16 | title=Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG) | year=2005 | author=Josting A, Rudolph C, Mapara M, Glossmann JP, Sieniawski M, Sieber M, Kirchner HH, Dörken B, Hossfeld DK, Kisro J, Metzner B, Berdel WE, Diehl V, Engert A | journal=Ann Oncol | pages=116–23}} 3. ^High Dose Sequential Therapy and Autologous Stem Cell Rescue for Multiple Myeloma 2 : Chemotherapy regimens used in lymphoma|Chemotherapy regimens used in multiple myeloma |
|||||||||||||||||||||||||
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。