Seán Burke or Sean Burke may refer to:

• Seán Burke (Gaelic footballer) (born 1970), Irish retired Gaelic footballer
• Seán Burke (hurler), Irish hurler
• Sean Burke (born 1967), Canadian former professional ice hockey goaltender
• Seán Burke (literary theorist) and author
• Sean M. Burke, author, linguist and programmer
• Shawn Burke, of Hamilton Tiger-Cats

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