| 词条 | SHINE Medical Technologies |
| 释义 |
| name = SHINE Medical Technologies | logo = SHINE Logo Sans MT Color PRESS READY@2x.png | type = | industry = Radiopharmaceutical | foundation = June 2010 | founder = Gregory Piefer | location_city = Janesville, Wisconsin | key_people = | num_employees = | homepage = http://ShineMed.com }}SHINE Medical Technologies, is a private corporation based in Janesville, Wisconsin USA which is building a facility to produce radioactive isotopes for medical applications.[1] SHINE is an acronym for Subcritical Hybrid Intense Neutron Emitter.[2] Business modelIn 2009, the supply of molybdenum-99 (Mo-99), a precursor to technetium-99m used in more than 30 medical imaging procedures, fell short of demand due to maintenance idling of a pair of research reactors, one located in the Netherlands, forcing doctors to use more dangerous isotopes.[3][4] By 2016, the largest global supplier of the isotope, a Canadian research reactor, was scheduled to go idle.[3][4] In 2010, the National Nuclear Security Administration (NNSA), a part of the United States Department of Energy, began funding a number of method development ventures aimed at ensuring that shortages in the United States could be avoided[4] as well as reducing the use of highly enriched uranium and with it lowering the risk of nuclear proliferation.[8] SHINE was among a handful of early recipients of funds from the NNSA program and received {{Currency|13.9 million}} through it as of 2014.[4] SHINE has also relied on venture capital funding, having secured up to {{Currency|125 million}} from Deerfield Management beginning in October 2014.[4][5] The 2014 market for medical isotopes was estimated to be about {{Currency|600 million}} per year.[4] Several companies in addition to SHINE are vying for part of this market, and the need for redundancy in production will support a number suppliers beyond the minimum needed to meet current demand.[4] The company plans to start production scale generation of isotope in 2018, having pushed the proposed start date back several times,[6] it has secured a number of supply agreements predicated on this start date.[4][7] In addition to supplying Mo-99, SHINE has secured a {{Currency|150,000}} National Science Foundation grant to develop production methods for Iodine-131, used in the treatment of Graves' disease and certain cancers.[8] Facilities and technologyOriginal technology for production of Mo-99 was reactor-based and unavoidably produced significant nuclear waste.[3] SHINE plans to use particle accelerator technology developed at the University of Wisconsin–Madison by company founder Gregory Piefer.[4][8] The method, referred to as "neutron generator technology", uses helium and free neutrons, produced by colliding a beam of deuterium particles with tritium gas, to bombard low-level enriched uranium targets leading to the production of "useful isotopes with minimal waste."[4] In addition to the diagnostically useful Mo-99, the process can also produce Iodine-131, used in medical treatments.[1] In 2013, SHINE constructed a full-scale prototype particle accelerator at their Monona, Wisconsin facility to be used to demonstrate the technology. Eight accelerators would be used at the Janesville facility.[9] On June 15, 2015, Argonne National Laboratory demonstrated that SHINE's production, separation and purification process could produce Mo-99 which meets purity specifications of the British Pharmacopoeia.[10] The NRC approved SHINE's construction permit for a facility in Janesville, Wisconsin in late February 2016. If constructed, the facility would still require NRC licensing to operate.[11] In 2014 the facility was originally slated for opening in 2016, was then delayed to 2017.[12] As of February 2016, construction was planned for 2017 with production potentially beginning in 2019.[11] References1. ^1 {{cite news|url = http://www.jsonline.com/business/shine-medical-technologies-receives-150000-national-science-foundation-grant-b99529497z1-310968511.html|title = Shine Medical Technologies receives $150,000 National Science Foundation grant|last = Gallagher|first = Kathleen |date = June 30, 2015|newspaper= The Milwaukee Journal Sentinel|access-date = 2015-07-24}} 2. ^{{cite web |url= http://mo99.ne.anl.gov/2011/pdfs/Mo99%202011%20Web%20Papers/S11-P2_Chemerisov-Paper.pdf |title= Development of the mini-SHINE/MIPS experiments |last= Chemerisov |first= S. |website= Argonne National Laboratory |date= April 14, 2014 |accessdate=July 17, 2015 |doi= 10.2172/1132249}} 3. ^1 2 {{cite journal|last1=Noorden |first1=Richard Van |title=Radioisotopes: The medical testing crisis|journal=Nature |date=December 11, 2013 |volume=504 |issue= 7479 |pages=202–204 |url=http://www.nature.com/news/radioisotopes-the-medical-testing-crisis-1.14325 |accessdate=14 July 2015 |issn=0028-0836 |PMID= 24336269 |doi= 10.1038/504202a}} 4. ^1 2 3 4 5 6 7 8 9 {{cite web |last = LaMonica|first = Martin|title = Startups Race to Solve Looming Medical Radioisotope Crisis|website = Xconomy|date = December 18, 2014|url = http://www.xconomy.com/wisconsin/2014/12/18/startups-race-to-solve-looming-medical-radioisotope-crisis/|accessdate = July 23, 2015|quote = The company has supply agreements in place and plans to build a production plant in Janesville, WI.}} 5. ^{{cite web | last=Engel | first=Jeff | title=Deerfield Pouring $125M Into WI Startup Shine Medical Technologies | website=Xconomy | date=October 9, 2014 | url=http://www.xconomy.com/wisconsin/2014/10/09/deerfield-pouring-125m-into-wi-startup-shine-medical-technologies/ | accessdate=July 23, 2015}} 6. ^{{cite news|last1 = Newman|first1 = Judy|title = Environmental report supports SHINE Medical's plan to build radioisotope plant in Janesville|url = http://host.madison.com/business/environmental-report-supports-shine-medical-s-plan-to-build-radioisotope/article_fabdf313-fe5a-529c-a6c4-b025f25aaeee.html|accessdate = July 23, 2015|newspaper= Wisconsin State Journal}} 7. ^{{cite news | last=Gallagher | first=Kathleen | title=Shine Medical Technologies signs supply contract with GE Healthcare |newspaper=Milwaukee Journal Sentinel | date=April 3, 2014 | url=http://www.jsonline.com/business/shine-medical-technologies-signs-supply-contract-with-ge-medical-b99239919z1-253794641.html | accessdate=July 23, 2015}} 8. ^1 {{cite news|last = Gallagher|first = Kathleen|title = Shine Medical Technologies raises $2.4 million|newspaper=Milwaukee Journal Sentinel|date = September 3, 2014|url = http://www.jsonline.com/business/shine-medical-technologies-raises-24-million-b99343758z1-273765531.html|accessdate = July 23, 2015}} 9. ^{{cite news |url= http://www.gazettextra.com/news/2013/feb/17/testing-1-2-3-shine-makes-progress-demonstration-f/ |title= Testing 1, 2, 3: SHINE makes progress at demonstration facility |first= Jim |last= Leute |newspaper= Janesville Gazette |date= February 17, 2013 |accessdate=July 17, 2015}} 10. ^1 {{cite web |url= http://www.anl.gov/articles/argonne-confirms-new-commercial-method-producing-medical-isotope |title= Argonne confirms new commercial method for producing medical isotope |website= Argonne National Lab |first= Greg |last= Cunningham |date= June 15, 2015 |accessdate=July 17, 2015 }} 11. ^1 {{cite news |url= http://host.madison.com/wsj/business/shine-medical-wins-nrc-s-ok-to-build-medical-isotope/article_971ae97c-9a7b-5147-8ded-07740210d37a.html |title= SHINE Medical wins NRC's OK to build medical isotope plant |newspaper= Wisconsin State Journal |first= Judy |last= Newman |date= February 25, 2016 |accessdate= February 25, 2016 }} 12. ^{{cite news|title = Financing deal for $125 million brings SHINE Janesville plant closer to reality|newspaper=The Janesville Gazette|date = October 10, 2014|url = http://www.gazettextra.com/20141010/financing_deal_for_125_million_brings_shine_janesville_plant_closer_to_reality|accessdate = July 23, 2015}}{{Subscription required}} External links
5 : 2010 establishments in Wisconsin|Nuclear medicine organisations|Dane County, Wisconsin|Rock County, Wisconsin|Health care companies based in Wisconsin |
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