| 词条 | Simple Modular Architecture Research Tool |
| 释义 |
|title = SMART |logo = |description = Identification scheme for protein domains. |scope = Protein domains |organism = all |center = European Molecular Biology Laboratory |laboratory = |author = |pmid = 18978020 |released = |standard = |format = |url = http://smart.embl-heidelberg.de |download = |webservice = |sql = |sparql = |webapp = |standalone = |license = Free to academics, but not commercial users |versioning = |frequency = |curation = Yes |bookmark = |version = 7 }} Simple Modular Architecture Research Tool (SMART) is a biological database that is used in the identification and analysis of protein domains within protein sequences.[1][2] SMART uses profile-hidden Markov models built from multiple sequence alignments to detect protein domains in protein sequences. The most recent release of SMART contains 1,204 domain models.[3] Data from SMART was used in creating the Conserved Domain Database collection and is also distributed as part of the InterPro database.[4] The database is hosted by the European Molecular Biology Laboratory in Heidelberg. References1. ^{{cite journal |vauthors=Schultz J, Milpetz F, Bork P, Ponting CP | title = SMART, a simple modular architecture research tool: identification of signaling domains | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 11 | pages = 5857–64 |date=May 1998 | pmid = 9600884 | pmc = 34487 | doi = 10.1073/pnas.95.11.5857| url = http://www.pnas.org/content/95/11/5857.full.pdf| issn = }} 2. ^{{cite journal |vauthors=Letunic I, Doerks T, Bork P | title = SMART 6: recent updates and new developments | journal = Nucleic Acids Res. | volume = 37 | issue = Database issue | pages = D229–32 |date=January 2009 | pmid = 18978020 | pmc = 2686533 | doi = 10.1093/nar/gkn808 | url = | issn = }} 3. ^{{Cite journal|last=Letunic|first=Ivica|last2=Doerks|first2=Tobias|last3=Bork|first3=Peer|date=January 2015|title=SMART: recent updates, new developments and status in 2015|journal=Nucleic Acids Research|volume=43|issue=Database issue|pages=D257–260|doi=10.1093/nar/gku949|issn=1362-4962|pmc=4384020|pmid=25300481}} 4. ^{{cite journal |vauthors=Mulder NJ, Apweiler R, Attwood TK, etal |title=InterPro: an integrated documentation resource for protein families, domains and functional sites |journal=Brief. Bioinformatics |volume=3 |issue=3 |pages=225–35 |date=September 2002 |pmid=12230031 |doi= 10.1093/bib/3.3.225|url=}} External links
3 : Protein structure|Protein classification|Biological databases |
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