| 词条 | SKBR3 |
| 释义 |
History and characteristicsSkBr3 cells were derived from a pleural effusion due to an adenocarcinoma originating in a 43-year-old caucasian female.[1] The cell line over-expresses the HER2 gene product, which has been implicated in several breast cancer proliferation pathways. The SkBr3 cell line is autologous (derived from the same patient) with the AU565 cell line.[2] The cells are considered biosafety level 1. They are known to grow in grape-like clusters with an invasive phenotype resembling that of the cells in vivo.[3] Research applicationsSkBr3 cells have been used in studies seeking to overcome Herceptin resistance to HER2-overexpressing breast cancers.[4] The cell line has also been examined for applications in CRISPR/Cas9 gene editing,[5] antibody resistance in transfections, and HER2-based cancer therapies in context of microenvironment fluctuations.[6] See also
References1. ^1 {{cite web|title=SK-BR-3: Human Breast Cancer Cell Line (ATCC HTB-30)|url=https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-breast-cell-line-sk-br-3|publisher=Memorial Sloan-Kettering Cancer Center|access-date=18 June 2018}} 2. ^{{cite web|url=http://www.addexbio.com/productdetail?pid=65|title=SK-BR-3 cells|publisher=Addex Bio|access-date=18 June 2018}} 3. ^{{cite journal|title=Choosing the right cell line for breast cancer research|first1=Deborah L |last1=Holliday |first2=Valerie |last2=Speirs|journal=Breast Cancer Research|date=12 August 2011|doi=10.1186/bcr2889|pmid=21884641 |pmc=3236329 |volume=13|issue=215|pages=215 }} 4. ^{{cite journal|title= Overcoming Trastuzumab Resistance in HER2-Overexpressing Breast Cancer Cells by Using a Novel Celecoxib-Derived Phosphoinositide-Dependent Kinase-1 Inhibitor|url=http://molpharm.aspetjournals.org/content/70/5/1534.full|doi=10.1124/mol.106.023911|pmid=16887935|first1=Ping-Hui |last1=Tseng|display-authors=etal|journal=Molecular Pharmacology|date=November 2006|volume=70|issue=5|pages=1534–1541}} 5. ^{{cite journal|title=An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting|pmc=5100567|journal=Nucleic Acids Research|volume=44|issue=19|pages=e149|doi=10.1093/nar/gkw660|pmid=27458201|first1=Jian|last1=Cao|display-authors=etal|date=2 November 2016}} 6. ^{{cite journal|title=HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment|journal=Breast Cancer Research and Treatment|first1=Britta |last1=Weigelt|display-authors=etal|doi=10.1007/s10549-009-0502-2|pmid=19701706|date=1 July 2011|volume=122|issue=1|pages=35–43|pmc=2935800}} External links
2 : Human cell lines|Breast cancer |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。