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词条 Slc22a21
释义

  1. Model organisms

  2. References

  3. Further reading

{{Orphan|date=August 2012}}Solute carrier family 22 (organic cation transporter), member 21 is a protein that in the house mouse is encoded by the Slc22a21 gene.[1] The gene is also known as Octn3 and Slc22a9.[1] Slc22a21 belongs to a protein family of solute carriers.[1]

Model organisms

Model organisms have been used in the study of Slc22a21 function. A conditional knockout mouse line, called Slc22a21tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[5]

References

1. ^1 2 {{cite web | title =Solute carrier family 22 (organic cation transporter), member 21| url = https://www.ncbi.nlm.nih.gov/gene/56517| accessdate = 2011-12-11}}
2. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHJ/indirect-calorimetry/ |title=Indirect calorimetry data for Slc22a21 |publisher=Wellcome Trust Sanger Institute}}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHJ/salmonella-challenge/ |title=Salmonella infection data for Slc22a21 |publisher=Wellcome Trust Sanger Institute}}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBHJ/citrobacter-challenge/ |title=Citrobacter infection data for Slc22a21 |publisher=Wellcome Trust Sanger Institute}}
5. ^1 2 {{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
6. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
7. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Slc22a21 |title=International Knockout Mouse Consortium}}
8. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4364715 |title=Mouse Genome Informatics}}
9. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }}
10. ^{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |journal=Nature |volume=474 |issue=7351 |pages=262–3 |date=June 2011 |pmid=21677718 |doi=10.1038/474262a }}
11. ^{{cite journal |vauthors=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |date=January 2007 |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}
12. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}}

Further reading

  • {{Cite journal

| last1 = Tamai | first1 = I.
| last2 = Ohashi | first2 = R.
| last3 = Nezu | first3 = J. I.
| last4 = Sai | first4 = Y.
| last5 = Kobayashi | first5 = D.
| last6 = Oku | first6 = A.
| last7 = Shimane | first7 = M.
| last8 = Tsuji | first8 = A.
| doi = 10.1074/jbc.M005340200
| title = Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice
| journal = Journal of Biological Chemistry
| volume = 275
| issue = 51
| pages = 40064–40072
| year = 2000
| pmid = 11010964
| pmc =
}}
  • {{Cite journal

| last1 = Monte | first1 = J. C.
| last2 = Nagle | first2 = M. A.
| last3 = Eraly | first3 = S. A.
| last4 = Nigam | first4 = S. K.
| title = Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa
| doi = 10.1016/j.bbrc.2004.08.112
| journal = Biochemical and Biophysical Research Communications
| volume = 323
| issue = 2
| pages = 429–436
| year = 2004
| pmid = 15369770
| pmc =
}}
  • {{Cite journal

| last1 = Lamhonwah | first1 = A. M.
| last2 = Ackerley | first2 = C. A.
| last3 = Tilups | first3 = A.
| last4 = Edwards | first4 = V. D.
| last5 = Wanders | first5 = R. J.
| last6 = Tein | first6 = I.
| doi = 10.1016/j.bbrc.2005.10.170
| title = OCTN3 is a mammalian peroxisomal membrane carnitine transporter
| journal = Biochemical and Biophysical Research Communications
| volume = 338
| issue = 4
| pages = 1966–1972
| year = 2005
| pmid = 16288981
| pmc =
}}
  • {{Cite journal

| last1 = Lamhonwah | first1 = A. M.
| last2 = Skaug | first2 = J.
| last3 = Scherer | first3 = S. W.
| last4 = Tein | first4 = I.
| title = A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5)
| journal = Biochemical and Biophysical Research Communications
| volume = 301
| issue = 1
| pages = 98–101
| year = 2003
| pmid = 12535646 | doi=10.1016/S0006-291X(02)02946-7
}}{{refend}}

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