| 词条 | Slippery sequence |
| 释义 |
A slippery sequence is a small section of codon nucleotide sequences (usually UUUAAAC) that controls the rate of ribosomal frameshifting. A slippery sequence causes a faster ribosomal transfer which in turn can cause the reading ribosome to "slip." This allows a tRNA to shift by 1 base after it has paired with its anticodon, changing the reading frame.[1][2][3][4][5] See also
References1. ^Green L, Kim CH, Bustamante C, Tinoco I Jr. "Characterization of the Mechanical Unfolding of RNA Pseudoknots." J Mol Biol. 26 May 2007 2. ^Chien-Hung Yu, Mathieu H. M. Noteborn and René C. L. Olsthoorn.Stimulation of ribosomal frameshifting by antisense LNA. Nucl.Acids Res (2010) 38 (22):8277-8238 3. ^{{cite web |url=http://www.path.cam.ac.uk/research/investigators/brierley/research.html |title=Archived copy |accessdate=2013-07-28 |deadurl=yes |archiveurl=https://web.archive.org/web/20131002121121/http://www.path.cam.ac.uk/research/investigators/brierley/research.html |archivedate=2013-10-02 |df= }} 4. ^{{cite web|url=http://molecularstudy.blogspot.com/2012/10/frameshifting-occurs-at-slippery.html |title=Molecular Biology: Frameshifting occurs at slippery sequences |publisher=Molecularstudy.blogspot.com |date= |accessdate=2013-07-28}} 5. ^{{cite journal|title=How translational accuracy influences reading frame maintenance|first1=P. J.|last1=Farabaugh|first2=G. R.|last2=Björk|date=15 March 1999|publisher=|journal=EMBO J.|volume=18|issue=6|pages=1427–1434|via=PubMed|doi=10.1093/emboj/18.6.1427|pmid=10075915|pmc=1171232}} External links
4 : RNA|Gene expression|Cis-regulatory RNA elements|Coronaviridae |
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