Soul Mates may refer to:

• Soul Mates (TV series), a 2014 Australian television comedy series
• "Soul Mates" (Babylon 5), a 1994 episode of television series Babylon 5
• Soul Mates (album), a jazz album by saxophonists Charlie Rouse and Sahib Shihab
• "The Soul Mate", a 1996 episode of television series Seinfeld
• Soul Mate #9, a 2001 song by Tina Arena
• Soul Mates (film), a 1925 silent drama
• Soul Mates, a track on Yorktown Heights (Grant Nicholas album)

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