Southern Discomfort may refer to:

• Southern Discomfort (Rita Mae Brown novel), a novel released in 1982 by Rita Mae Brown
• Southern Discomfort (Eyehategod album), an album released in 2000 by Sludge metal band Eyehategod
• Southern Discomfort (Rehab album), is an album released in 2000 by rock band Rehab
• Southern Discomfort (Fabian Society pamphlets), a series of pamphlets that examined attitudes to the British Labour Party in the south of England
• Southern Discomfort Roller Derby, a men's roller derby league based in London
• "Southern Discomfort", an episode of the seventh season of the American reality television series The Real Housewives of Atlanta

• Apatele cerasi
• Apatelodes torrefacta
• Apatelomyces
• Apatelomyces ogmoceri
• Apatelopteryx
• Apatema husadeli
• Apatemyia
• Apatemyidae
• Apateodus
• Apateon
• Apateopholis
• Apateta
• Apatetris
• Apatfalva, Hungary
• APA - The Engineered Wood Association
• Apatheia
• Apathetic Agnostic
• Apathetically
• Apathies
• Apathy is Boring
• Apatia
• Apatia (punk rock band)
• Apatichnus
• Apatinib
• Apatinska pivara