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词条 SOX2OT
释义

  1. See also

  2. References

  3. Further reading

{{Infobox_gene}}

SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies within one of the introns of SOX2OT.[1] SOX2OT and SOX2DOT (an isoform of SOXOT transcribed from a distal highly conserved element) are expressed in zones of neurogenesis within the brain. It is associated with central nervous system structures in zebrafish and chicken embryonic brains, and is dynamically regulated during embryogenesis.[2] SOX2OT may play a role in vertebrate development.[2]

See also

  • Long noncoding RNA

References

1. ^{{cite journal |vauthors=Fantes J, Ragge NK, Lynch SA, etal |title=Mutations in SOX2 cause anophthalmia |journal=Nat. Genet. |volume=33 |issue=4 |pages=461–3 |date=April 2003 |pmid=12612584 |doi=10.1038/ng1120 |url=}}
2. ^1 {{cite journal |vauthors=Amaral PP, Neyt C, Wilkins SJ, etal |title=Complex architecture and regulated expression of the Sox2ot locus during vertebrate development |journal=RNA |volume=15 |issue=11 |pages=2013–27 |date=November 2009 |pmid=19767420 |pmc=2764477 |doi=10.1261/rna.1705309 |url=}}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129}}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
{{refend}}

1 : Non-coding RNA
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