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词条 Spillover infection
释义

  1. Spillover zoonoses

  2. Intraspecies spillover

  3. See also

  4. References

  5. External links

Spillover infection, also known as pathogen spillover and spillover event, occurs when a reservoir population with a high pathogen prevalence comes into contact with a novel host population. The infection is transmitted from the reservoir population and may or may not be transmitted within the host population.[1]

Spillover zoonoses

Spillover is a common event; in fact, more than two thirds of human viruses are zoonotic [2]. Most spillover events result in self-limited cases with no further human to human transmission, as occurs, for example, with rabies, antrax, histoplasmosis or hidatidosis. Other zoonotic pathogens are able to be transmitted by humans to produce secondary cases and even to establish limited chains of transmission. Some examples are the Ebola and Marburg filoviruses, the MERS and SARS coronaviruses or some avian flu viruses. Finally some few spillover events can result in the final adaptation of the microbe to the humans, who became a new stable reservoir, as occurred with the HIV virus resulting in the AIDS pandemic. In fact, most of the pathogens which are presently exclusive of humans were probably transmitted by animals sometime in the past [3]. If the history of mutual adaptation is long enough, permanent host-microbe associations can be established resulting in co-evolution, and even on permanent integration of the microbe genome in the human genome, as it is the case of endogenous viruses. The closer the two species are in phylogenetic terms, the easier it is for microbes to overcome the biological barrier to produce successful spillovers. For this reason, other mammals are the main source of zoonotic agents for humans.

Intraspecies spillover

Commercially bred bumblebees used to pollinate greenhouses can be reservoirs for several pollinator parasites including the protozoans Crithidia bombi, and Apicystis bombi,[4] the Microsporidians Nosema bombi and Nosema ceranae,[4][5] plus viruses such as Deformed wing virus and the tracheal mites Locustacarus buchneri.[5] Commercial bees that escape the glasshouse environment may then infect wild bee populations. Infection may be via direct interactions between managed and wild bees or via shared flower use and contamination.[6][7] One study found that half of all wild bees found near greenhouses were infected with C. bombi. Rates and incidence of infection decline dramatically the further away from the greenhouses the wild bees are located.[8][9] Instances of spillover between bumblebees are well documented across the world but particularly in Japan, North America and the United Kingdom.[10][11]

See also

  • Infection
  • 1993 Four Corners hantavirus outbreak
  • Outbreak
  • Epidemic
  • List of Legionellosis outbreaks
  • Cross-species transmission

References

1. ^{{cite journal | last1 = Power | first1 = AG | last2 = Mitchell | first2 = CE | date = Nov 2004 | title = Pathogen spillover in disease epidemics | url = | journal = Am Nat | volume = 164 | issue = Suppl 5| pages = S79–89 }}
2. ^Woolhouse M, Scott F, Hudson Z, Howey R, Chase-Topping M. Human viruses: discovery and emergence. Phil. Trans. R. Soc. B (2012) 367, 2864–2871
3. ^Wolfe ND, Dunavan CP, Diamond J Origins of major human infectious diseases. Nature, 477: 279-283.
4. ^1 {{cite journal | last1 = Graystock | first1 = P | last2 = Yates | first2 = K | last3 = Evison | first3 = SEF | last4 = Darvill | first4 = B | last5 = Goulson | first5 = D | last6 = Hughes | first6 = WOH | year = 2013| title = The Trojan hives: pollinator pathogens, imported and distributed in bumblebee colonies | doi = 10.1111/1365-2664.12134 | journal = Journal of Applied Ecology | volume = 50 | issue = 5| pages = 1207–15 }}
5. ^1 {{Cite journal|title = Commercial Bombus impatiens as reservoirs of emerging infectious diseases in central México|journal = Biological Invasions|date = 2015-03-10|issn = 1387-3547|pages = 2043–53|volume = 17|issue = 7|doi = 10.1007/s10530-015-0859-6|first = Bernardo|last = Sachman-Ruiz|first2 = Verónica|last2 = Narváez-Padilla|first3 = Enrique|last3 = Reynaud}}
6. ^{{Cite journal|title = Shared Use of Flowers Leads to Horizontal Pathogen Transmission|url = http://rspb.royalsocietypublishing.org/content/258/1353/299|journal = Proceedings of the Royal Society of London B: Biological Sciences|date = 1994-12-22|issn = 0962-8452|pages = 299–302|volume = 258|issue = 1353|doi = 10.1098/rspb.1994.0176|first = Stephan|last = Durrer|first2 = Paul|last2 = Schmid-Hempel}}
7. ^{{Cite journal|title = Parasites in bloom: flowers aid dispersal and transmission of pollinator parasites within and between bee species|url = http://rspb.royalsocietypublishing.org/content/282/1813/20151371|journal = Proc. R. Soc. B|date = 2015-08-22|issn = 0962-8452|pmc = 4632632|pmid = 26246556|pages = 20151371|volume = 282|issue = 1813|doi = 10.1098/rspb.2015.1371|first = Peter|last = Graystock|first2 = Dave|last2 = Goulson|first3 = William O. H.|last3 = Hughes}}
8. ^{{cite journal | last1 = Otterstatter | first1 = MC | last2 = Thomson | first2 = JD | year = 2008| title = Does Pathogen Spillover from Commercially Reared Bumble Bees Threaten Wild Pollinators? | journal = PLOS ONE | volume = 3 | issue = 7| page = e2771 | doi=10.1371/journal.pone.0002771 | pmid=18648661 | pmc=2464710}}
9. ^{{Cite journal|title = The relationship between managed bees and the prevalence of parasites in bumblebees|url = https://peerj.com/articles/522|journal = PeerJ|pmc = 4137657|pmid = 25165632|volume = 2|doi = 10.7717/peerj.522|first = Peter|last = Graystock|first2 = Dave|last2 = Goulson|first3 = William O.H.|last3 = Hughes|pages=e522|year=2014}}
10. ^{{Cite journal|title = Do managed bees drive parasite spread and emergence in wild bees?|url = http://www.sciencedirect.com/science/article/pii/S2213224415300158|journal = International Journal for Parasitology: Parasites and Wildlife|doi = 10.1016/j.ijppaw.2015.10.001|pmid = 28560161|first = Peter|last = Graystock|first2 = Edward J.|last2 = Blane|first3 = Quinn S.|last3 = McFrederick|first4 = Dave|last4 = Goulson|first5 = William O. H.|last5 = Hughes|volume=5|pages=64–75|year=2016}}
11. ^Imported bumblebees pose risk to UK's wild and honeybee population. Damian Carrington. theguardian.com, Thursday 18 July 2013

External links

  • Infection Information Resource
  • European Center for Disease Prevention and Control
  • [https://www.cdc.gov/ U.S. Centers for Disease Control and Prevention],
  • Infectious Disease Society of America (IDSA)
{{Infectious disease|state=expanded}}

3 : Epidemiology|Viruses|Zoonoses
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