“Splicing regulatory element”的意思、由来-开放百科全书

词条

Splicing regulatory element

释义

References

Splicing regulatory element (SRE) are cis-acting sequences in pre-mRNA, which either enhance or silence (suppress) the splicing of introns, or in general regulates the constitutive or alternative splicing of this pre-mRNA. SREs recruit trans-acting splicing factors to activate or suppress the splice site recognition or spliceosome assembly. The "context dependence" of SREs is categorized into at least two studied groups: (a) the location-dependent activity of SREs: the activity varies with the relative positions of SREs in pre-mRNA; (b) the gene-dependent activity of SREs: the SRE activity observed in one gene is lost when the SRE is moved to another gene.^[1]

SREs are:

present in exons: exonic splicing enhancers (ESEs), exonic splicing silencers (ESSs)

present in introns: intronic splicing enhancers (ISEs), intronic splicing silencers (ISSs).

References

1. ^{{Cite journal| doi = 10.1261/rna.876308| issn = 1355-8382| volume = 14| issue = 5| pages = 802–813| last = Wang| first = Zefeng|author2=Christopher B. Burge| title = Splicing regulation: From a parts list of regulatory elements to an integrated splicing code| journal = RNA| date = May 2008| pmid=18369186| pmc=2327353}}

2 : Spliceosome|RNA splicing

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。