“SSMEM1”的意思、由来-开放百科全书

Serine-rich single pass membrane protein 1 is a protein that in humans is encoded by the SSMEM1 gene.^[1]

Gene

The gene and intron-exon structure were first predicted through analysis of the complete sequence of human chromosome 7, its initial designation being C7orf45.^[2]^[3] Human mRNA transcripts were identified through two large scale cDNA cloning efforts, an American effort run out of the Dana-Farber Cancer Institute and Harvard Medical School, and full-length long Japan effort. Later assigned the official symbol SSMEM1, the gene is located on the long arm of chromosome 7 (7q32.2) on the sense strand in humans.^[4] The human mRNA transcript is 1171 bp long with three exons.^[5]

Aliases

In humans, SSMEM1 is also referred to as C7orf45.^[4] Human SSMEM1 has a clone name of FLJ40316.^[4]

Expression

In humans, SSMEM1 is highly expressed in the testes.^[6]{{Failed verification|date=December 2016}}^[7]^[8] In mice, SSMEM1 is expressed in the brain.^[9]

Protein

In humans, serine-rich single pass membrane protein 1 is 244 amino acids long with a transmembrane domain region spanning amino acids 35-55.^[1] This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243).^[1] DUF4636 belongs to pfam15468 which is a part of the superfamily cl21285 that is found in eukaryotes and typically 196 to 244 amino acids long.^[1] The human protein has a molecular weight of 28036 Da and an isoelectric point of 7.64.^[1]^[10]

References

1. ^¹²³⁴{{Cite encyclopedia|title=serine-rich single-pass membrane protein 1 [Homo sapiens]|encyclopedia=Protein|publisher=NCBI|id=NP_660311.1|url=https://www.ncbi.nlm.nih.gov/protein/NP_660311.1|accessdate=2016-12-16|date=26 August 2016|at=}}
2. ^{{Cite web|url=http://www.chr7.org/cgi-bin/gbrowse/gbrowse/chr7_v2/?name=Gene%3AC7orf45%7CNM_145268.2;addlabel=NCBI_RefSeq|title=Showing 9.782 kbp from Chr7, positions 129,233,084 to 129,242,865|last=|first=|date=June 2004|website=|publisher=The Chromosome 7 Annotation Project|at=Landmark or Region: Gene:C7orf45{{!}}NM_145268.2|access-date=2016-12-16}}
3. ^{{Cite journal|last=|first=|year=2003|title=Human Chromosome 7: DNA Sequence and Biology|url=|journal=Science|volume=300|issue=5620|pages=767–772|doi=10.1126/science.1083423|pmc=2882961|via=|vauthors=Scherer SW, Cheung J, MacDonald JR, et al.|pmid=12690205}}
4. ^¹²{{Cite encyclopedia|title=SSMEM1 serine rich single-pass membrane protein 1 [ Homo sapiens (human) ]|encyclopedia=Gene|publisher=NCBI|id=136263|url=https://www.ncbi.nlm.nih.gov/gene?LinkName=protein_gene&from_uid=21687171|accessdate=2016-12-16|date=6 December 2016}}
5. ^{{Cite encyclopedia|title=Homo sapiens serine rich single-pass membrane protein 1 (SSMEM1), mRNA|encyclopedia=Nucleotide|publisher=NCBI|id=NM_145268.3|url=https://www.ncbi.nlm.nih.gov/nuccore/197304739|accessdate=2016-12-16|date=26 August 2016}}
6. ^http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/8586006
7. ^{{Cite encyclopedia|title=Est Profile - Hs.351816|encyclopedia=UniGene|publisher=NCBI|url=https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.351816|date=2016}}
8. ^{{Cite web|url=https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3834:4246|title=GDS3834 / 4246|website=www.ncbi.nlm.nih.gov|access-date=2016-12-17}}
9. ^{{Cite web|url=http://mouse.brain-map.org/gene/show/51488|title=Gene Detail :: Allen Brain Atlas: Mouse Brain|website=mouse.brain-map.org|access-date=2016-12-17}}
10. ^{{Cite web|url=http://www.phosphosite.org/proteinAction.do?id=13271515&showAllSites=true|title=SSMEM1 (human)|website=www.phosphosite.org|access-date=2016-12-17}}