| 词条 | Stephen C. Harrison |
| 释义 |
| name = Stephen Harrison |birth_name = Stephen C. Harrison | image = Professor Stephen Harrison ForMemRS.jpg | imagesize = | alt = | caption = Stephen Harrison in 2014, portrait via the Royal Society | birth_date = | birth_place = | death_date = | death_place = | death_cause = | resting_place = | resting_place_coordinates = | other_names = | residence = | citizenship = | nationality = | fields = | workplaces = | patrons = | alma_mater = Harvard University (BA, PhD) | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = | influences = | influenced = | awards = | spouse = | partner = | children = | signature = | signature_alt = | website = {{URL|https://crystal.harvard.edu/harrison.html}} | footnotes = }}Stephen C. Harrison is professor of biological chemistry and molecular pharmacology, professor of pediatrics, and director of the Center for Molecular and Cellular Dynamics of Harvard Medical School, head of the Laboratory of Molecular Medicine at Boston Children's Hospital, and investigator of the Howard Hughes Medical Institute.[1] Education and careerHe received his B.A. in chemistry and physics from Harvard in 1963, and was then a Henry fellow at the MRC Laboratory of Molecular Biology at Cambridge. In 1967, he received his Ph.D. in biophysics from Harvard, was a research fellow there as well as a junior fellow in the Society of Fellows, and joined the Harvard faculty in 1971. ResearchHis wide-ranging studies of protein structure have contributed insights to viral architecture, DNA–protein recognition, and cellular signaling. Harrison has made important contributions to structural biology, most notably by determining and analyzing the structures of viruses and viral proteins, by crystallographic analysis of protein–DNA complexes,[2][3] and by structural studies of protein-kinase switching mechanisms.[4] The initiator of high-resolution virus crystallography, he has moved from his early work on tomato bushy stunt virus [5] (1978) to the study of more complex human pathogens, including the capsid of human papillomavirus,[6] the envelope of dengue virus,[7] and several components of HIV.[8] He has also turned some of his research attention to even more complex assemblies, such as clathrin-coated vesicles.[9] He led the Structural Biology team at the Center for HIV/AIDS Vaccine Immunology (CHAVI) when it received National Institute of Allergy and Infectious Diseases (NIAID) funding [10] of around $300 million to address key immunological roadblocks to HIV vaccine development and to design, develop and test novel HIV vaccine candidates. Society membershipsHe is a member of American Academy of Arts and Sciences, National Academy of Sciences, American Philosophical Society, European Molecular Biology Organization, American Crystallographic Association and American Association for the Advancement of Science. Awards
References1. ^{{cite web|url=http://www.newsrx.com/newsletters/AIDS-Vaccine-Week/2005-08-22/082220053336AV.html |title=Awards - Stephen C. Harrison wins Bristol-Myers Squibb infectious diseases r |publisher=Newsrx.com |date=2005-08-22 |accessdate=2013-01-29}} {{FRS 2014}}{{Authority control}}{{DEFAULTSORT:Harrison, Stephen C.}}2. ^{{cite journal |vauthors=Anderson JE, Ptashne M, Harrison SC |title=Structure of the repressor-operator complex of bacteriophage 434 |journal=Nature |volume=326 |issue=6116 |pages=846–52 |year=1987 |pmid=3553959 |doi=10.1038/326846a0 |url=}} 3. ^{{cite journal |vauthors=Ellenberger TE, Brandl CJ, Struhl K, Harrison SC |title=The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex |journal=Cell |volume=71 |issue=7 |pages=1223–37 |date=December 1992 |pmid=1473154 |doi= 10.1016/s0092-8674(05)80070-4|url=}} 4. ^{{cite journal |vauthors=Xu W, Harrison SC, Eck MJ |title=Three-dimensional structure of the tyrosine kinase c-Src |journal=Nature |volume=385 |issue=6617 |pages=595–602 |date=February 1997 |pmid=9024657 |doi=10.1038/385595a0 |url=}} 5. ^{{cite journal |author=Harrison SC |title=Structure of tomato bushy stunt virus. I. The spherically averaged electron density |journal=J. Mol. Biol. |volume=42 |issue=3 |pages=457–83 |date=June 1969 |pmid=5804155 |doi=10.1016/0022-2836(69)90236-8 }} 6. ^{{cite journal |vauthors=Modis Y, Trus BL, Harrison SC |title=Atomic model of the papillomavirus capsid |journal=EMBO J. |volume=21 |issue=18 |pages=4754–62 |date=September 2002 |pmid=12234916 |pmc=126290 |doi= 10.1093/emboj/cdf494|url=}} 7. ^{{cite journal |vauthors=Modis Y, Ogata S, Clements D, Harrison SC |title=Structure of the dengue virus envelope protein after membrane fusion |journal=Nature |volume=427 |issue=6972 |pages=313–9 |date=January 2004 |pmid=14737159 |doi=10.1038/nature02165 |url=}} 8. ^{{cite journal |vauthors=Huang H, Chopra R, Verdine GL, Harrison SC |title=Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance |journal=Science |volume=282 |issue=5394 |pages=1669–75 |date=November 1998 |pmid=9831551 |doi= 10.1126/science.282.5394.1669|url=}} 9. ^{{cite web |url=http://chavi.org/about-chavi/investigators/stephen-c-harrison-phd |title=Archived copy |accessdate=2013-01-12 |deadurl=yes |archiveurl=https://web.archive.org/web/20140514054328/http://chavi.org/about-chavi/investigators/stephen-c-harrison-phd |archivedate=2014-05-14 |df= }} 10. ^{{cite web|url=http://www.niaid.nih.gov/news/newsreleases/2005/pages/chavi.aspx |title=NIAID Funds Center for HIV/AIDS Vaccine Immunology (CHAVI) |publisher=Niaid.nih.gov |date=2005-07-14 |accessdate=2013-01-29}} 11. ^{{cite web |url=https://royalsociety.org/people/fellowship/2014/stephen-harrison/ |title=Professor Stephen Harrison ForMemRS}} 10 : Structural biology|Crystallographers|HIV/AIDS researchers|Harvard University alumni|Members of the United States National Academy of Sciences|Howard Hughes Medical Investigators|Living people|Foreign Members of the Royal Society|Year of birth missing (living people)|LGBT scientists |
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