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词条 Stephen O'Rahilly
释义

  1. Education

  2. Research

  3. Awards and honours

  4. Personal Life

  5. References

{{EngvarB|date=August 2017}}{{Use dmy dates|date=August 2017}}{{Infobox scientist
| name = Professor Sir Stephen O'Rahilly
| birth_name = Stephen Patrick O'Rahilly
| native_name_lang =
| image = Professor Sir Stephen O'Rahilly.jpg
| image_size =
| alt =
| caption =
| fields = {{Plainlist|
  • Genetics of obesity
  • Childhood obesity}}

| birth_date = {{Birth date and age|df=yes|1958|04|01}}[1]
| birth_place =
| death_date =
| death_place =
| citizenship = Ireland, United Kingdom
| workplaces = {{Plainlist|
  • University of Cambridge
  • University of Oxford
  • Harvard Medical School
  • University College Dublin
  • Addenbrooke's Hospital
  • St Bartholomew's Hospital
  • Sanger Institute[1]
  • Hammersmith Hospital[1]}}

| alma_mater = University College Dublin
| influenced = Sadaf Farooqi[2]
| awards = {{Plainlist|
  • MD
  • FRCP
  • FRCPI
  • FMedSci
  • FRCPath
  • FRS (2003)
  • FRSB
  • Knight Bachelor (2013)
  • MRIA (2017)}}

| website = {{Plainlist|
  • {{URL|www.mrl.ims.cam.ac.uk/research/principal-investigators/professor-sir-stephen-orahilly}}
  • }}

}}Professor Sir Stephen Patrick O'Rahilly {{post-nominals|country=GBR|MD|FRS|FRCP|FRCPI|FRCPath|FMedSci|FRSB|MRIA}} is an Irish-British physician and scientist known for his research into the molecular pathogenesis of human obesity, insulin resistance and related metabolic and endocrine disorders.[3][4][5][6][7][8][9][10][11]

Education

O'Rahilly was born in Dublin, Ireland[12] and educated at Beneavin College.[1] He attended University College Dublin to study medicine[12]

Research

O'Rahilly undertook research into Type 2 diabetes and insulin resistance at the University of Oxford and Harvard Medical School, before joining the University of Cambridge where he is a Professor of Clinical Biochemistry and Medicine, Director of the University of Cambridge Metabolic Research Laboratories,[13] Director of the MRC Metabolic Diseases Unit [13] and co-director of the Wellcome Trust-MRC Institute of Metabolic Science. He is also the scientific Director of the NIHR Cambridge Biomedical Research Centre, Associate Faculty at the Wellcome Trust Sanger Institute and honorary consultant physician at Addenbrooke's Hospital, Cambridge.[14][15][16] He is a professorial fellow of Pembroke College, Cambridge.

Awards and honours

O'Rahilly was elected to the Academy of Medical Sciences in 1999, the Royal Society in 2003. His nomination reads: {{centred pull quote|Stephen O'Rahilly has made major contributions to the understanding of the molecular mechanisms underlying human disorders of energy balance and metabolism. His work first established that mutations in single genes could result in severe human obesity and that these defects largely acted through disruption of central satiety mechanisms. These findings have altered clinical approaches to the evaluation of the obese child and have identified a subtype of obesity amenable to dramatically effective therapy. His studies of patients with extreme insensitivity to insulin have also provided new insights into human insulin action and its disruption in states of insulin resistance.[17]}} O'Rahilly became a Foreign Associate of the National Academy of Sciences, in the US in 2011. He was awarded the Heinrich Wieland Prize[18] in 2002, the InBev-Baillet Latour Health Prize in 2010[19] and the Debrecen Award for Molecular Medicine in 2014.[20] He delivered the 2016 Harveian Oration[21] at the Royal College of Physicians of London.

O'Rahilly was knighted in the 2013 Birthday Honours for services to medical research.[22][23]

Personal Life

O’Rahilly lives in Cambridge, England with his wife, journalist Philippa Lamb, and his stepson Felix Lamb. He was married to Suzy Oakes from 1990 until her death in 2011.

References

1. ^1 2 3 {{Who's Who | surname = O'RAHILLY | othernames = Prof. Stephen | id = U28931 | volume = 2015 | edition = online Oxford University Press}} {{subscription required}}
2. ^{{cite journal|last1=Farooqi|first1=I. Sadaf|last2=O'Rahilly|first2=Stephen|title=Genetics of Obesity in Humans|journal=Endocrine Reviews|volume=27|issue=7|year=2006|pages=710–718|pmid= 17122358 |doi=10.1210/er.2006-0040}}
3. ^{{Cite journal | last1 = Neill | first1 = U. S. | title = A conversation with Stephen O'Rahilly | doi = 10.1172/JCI70726 | journal = Journal of Clinical Investigation | volume = 123 | issue = 6 | pages = 2335–2336 | year = 2013 | pmid = 23722908| pmc =3668822 }}
4. ^{{Cite journal | last1 = Weston | first1 = K. | title = Translating metabolic biochemistry into the clinic: An interview with Steve O'Rahilly | doi = 10.1242/dmm.007641 | pmid = 21357759 | pmc = 3046085 | journal = Disease Models & Mechanisms | volume = 4 | issue = 2 | pages = 141–144 | year = 2011 }}
5. ^{{Cite journal | last1 = Gerken | first1 = T. | last2 = Girard | first2 = C. A. | last3 = Tung | first3 = Y. -C. L. | last4 = Webby | first4 = C. J. | last5 = Saudek | first5 = V. | last6 = Hewitson | first6 = K. S. | last7 = Yeo | first7 = G. S. H. | last8 = McDonough | first8 = M. A. | last9 = Cunliffe | first9 = S. | last10 = McNeill | doi = 10.1126/science.1151710 | first10 = L. A. | last11 = Galvanovskis | first11 = J. | last12 = Rorsman | first12 = P. | authorlink12 = Patrik Rorsman| last13 = Robins | first13 = P. | last14 = Prieur | first14 = X. | last15 = Coll | first15 = A. P. | last16 = Ma | first16 = M. | last17 = Jovanovic | first17 = Z. | last18 = Farooqi | first18 = I. S. | authorlink18 = Sadaf Farooqi| last19 = Sedgwick | first19 = B. | last20 = Barroso | first20 = I. | last21 = Lindahl | first21 = T. | authorlink21 = Tomas Lindahl| last22 = Ponting | first22 = C. P. | authorlink22 = Chris Ponting| last23 = Ashcroft | first23 = F. M. | authorlink23 = Frances Ashcroft| last24 = O'Rahilly | first24 = S. | authorlink24 = Stephen O'Rahilly| last25 = Schofield | first25 = C. J. | authorlink25 = Christopher J. Schofield| title = The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase | journal = Science | volume = 318 | issue = 5855 | pages = 1469–1472 | year = 2007 | pmid = 17991826| pmc =2668859 }}
6. ^{{Scopus|id=7101607650}}
7. ^{{Cite journal | doi = 10.1038/43185| pmid = 9202122| year = 1997| journal = Nature| volume = 387| issue = 6636| pages = 903–8| last2 = Montague | first2 = C. T. | last3 = Farooqi | first3 = I. S. |authorlink3=Sadaf Farooqi| last4 = Whitehead | first4 = J. P. | last5 = Soos | first5 = M. A. | last6 = Rau | first6 = H. | last7 = Wareham | first7 = N. J. | last8 = Sewter | first8 = C. P. | last9 = Digby | first9 = J. E. | last10 = Mohammed | first10 = S. N. | last11 = Hurst | first11 = J. A. | last12 = Cheetham | first12 = C. H. | last13 = Earley | first13 = A. R. | last14 = Barnett | first14 = A. H. | last15 = Prins | first15 = J. B. | last1 = Oʼrahilly| first1 = Stephen| title = Congenital leptin deficiency is associated with severe early-onset obesity in humans}}
8. ^{{Cite journal | doi = 10.1056/NEJMoa035322| title = TheGPR54Gene as a Regulator of Puberty| journal = New England Journal of Medicine| volume = 349| issue = 17| pages = 1614–27| year = 2003| last1 = Seminara | first1 = S. B. | last2 = Messager | first2 = S. | last3 = Chatzidaki | first3 = E. E. | last4 = Thresher | first4 = R. R. | last5 = Acierno | first5 = J. S. | last6 = Shagoury | first6 = J. K. | last7 = Bo-Abbas | first7 = Y. | last8 = Kuohung | first8 = W. | last9 = Schwinof | first9 = K. M. | last10 = Hendrick | first10 = A. G. | last11 = Zahn | first11 = D. | last12 = Dixon | first12 = J. | last13 = Kaiser | first13 = U. B. | last14 = Slaugenhaupt | first14 = S. A. | last15 = Gusella | first15 = J. F. | last16 = O'Rahilly | first16 = S. | last17 = Carlton | first17 = M. B. L. | last18 = Crowley | first18 = W. F. | last19 = Aparicio | first19 = S. A. J. R. | last20 = Colledge | first20 = W. H. | pmid=14573733}}
9. ^{{Cite journal | doi = 10.1056/NEJM199909163411204| title = Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency| journal = New England Journal of Medicine| volume = 341| issue = 12| pages = 879–84| year = 1999| last1 = Farooqi | first1 = I. S | authorlink1=Sadaf Farooqi | last2 = Jebb | first2 = S. A. | last3 = Langmack | first3 = G. | last4 = Lawrence | first4 = E. | last5 = Cheetham | first5 = C. H. | last6 = Prentice | first6 = A. M. | last7 = Hughes | first7 = I. A. | last8 = McCamish | first8 = M. A. | last9 = O'Rahilly | first9 = S. | pmid=10486419}}
10. ^{{Cite journal | doi = 10.1073/pnas.1408523111| title = Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease| journal = Proceedings of the National Academy of Sciences| volume = 111| issue = 24| pages = 8901–8906| year = 2014| last1 = Payne | first1 = F.| last2 = Lim | first2 = K.| last3 = Girousse | first3 = A.| last4 = Brown | first4 = R. J.| last5 = Kory | first5 = N.| last6 = Robbins | first6 = A.| last7 = Xue | first7 = Y.| last8 = Sleigh | first8 = A.| last9 = Cochran | first9 = E.| last10 = Adams | first10 = C.| last11 = Dev Borman | first11 = A.| last12 = Russel-Jones | first12 = D.| last13 = Gorden | first13 = P.| last14 = Semple | first14 = R. K.| last15 = Saudek | first15 = V.| last16 = O'Rahilly | first16 = S.| last17 = Walther | first17 = T. C.| last18 = Barroso | first18 = I.| last19 = Savage | first19 = D. B. | pmid=24889630 | pmc=4066527}}
11. ^{{cite web|archiveurl=https://web.archive.org/web/20140413082922/http://www.clbc.cam.ac.uk/SOR/orahilly.html|archivedate=2014-04-13|publisher=University of Cambridge|title=Professor Steve O'Rahilly, Head of Department and Professor of Clinical Biochemistry and Medicine|url=http://www.clbc.cam.ac.uk/SOR/orahilly.html}}
12. ^1 Ellen Ruppel Shell, Fat Genes, Discover Magazine, 1 May 2000
13. ^1 {{cite web|url=http://www.mrl.ims.cam.ac.uk/staff/hod|archiveurl=https://web.archive.org/web/20140614184726/http://www.mrl.ims.cam.ac.uk/staff/hod|title=Stephen O'Rahilly, University of Cambridge Metabolic Research Laboratories|archivedate=2014-06-14}}
14. ^{{cite web|url=http://www.cambridge-brc.org.uk/nihr-cambridge-biomedical-research-centre|title=NIHR Cambridge Biomedical Research Centre Web Site}}{{dead link|date=June 2016|bot=medic}}{{cbignore|bot=medic}}
15. ^{{Cite journal |pmid = 23712428|pmc = 3674708|year = 2013|author1 = Roberts|first1 = E. W.|title = Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia|journal = Journal of Experimental Medicine|volume = 210|issue = 6|pages = 1137–51|last2 = Deonarine|first2 = A|last3 = Jones|first3 = J. O.|last4 = Denton|first4 = A. E.|last5 = Feig|first5 = C|last6 = Lyons|first6 = S. K.|last7 = Espeli|first7 = M|last8 = Kraman|first8 = M|last9 = McKenna|first9 = B|last10 = Wells|first10 = R. J.|last11 = Zhao|first11 = Q|last12 = Caballero|first12 = O. L.|last13 = Larder|first13 = R|last14 = Coll|first14 = A. P.|last15 = O'Rahilly|first15 = S|authorlink15 = Stephen O'Rahilly|last16 = Brindle|first16 = K. M.|last17 = Teichmann|first17 = S. A.|authorlink17 = Sarah Teichmann|last18 = Tuveson|first18 = D. A.|last19 = Fearon|first19 = D. T.|authorlink19 = Douglas Fearon|doi = 10.1084/jem.20122344}}{{Open access}}
16. ^{{Cite journal | pmid = 18454148| pmc = 2669167| year = 2008| author1 = Loos| first1 = R. J.| title = Common variants near MC4R are associated with fat mass, weight and risk of obesity| journal = Nature Genetics| volume = 40| issue = 6| pages = 768–75| last2 = Lindgren| first2 = C. M.| last3 = Li| first3 = S| last4 = Wheeler| first4 = E| last5 = Zhao| first5 = J. H.| last6 = Prokopenko| first6 = I| last7 = Inouye| first7 = M| last8 = Freathy| first8 = R. M.| last9 = Attwood| first9 = A. P.| last10 = Beckmann| first10 = J. S.| last11 = Berndt| first11 = S. I.| last12 = Prostate| first12 = Lung| last13 = Jacobs| first13 = K. B.| last14 = Chanock| first14 = S. J.| last15 = Hayes| first15 = R. B.| last16 = Bergmann| first16 = S| last17 = Bennett| first17 = A. J.| last18 = Bingham| first18 = S. A.| last19 = Bochud| first19 = M| last20 = Brown| first20 = M| last21 = Cauchi| first21 = S| last22 = Connell| first22 = J. M.| last23 = Cooper| first23 = C| last24 = Smith| first24 = G. D.| last25 = Day| first25 = I| last26 = Dina| first26 = C| last27 = De| first27 = S| last28 = Dermitzakis| first28 = E. T.| last29 = Doney| first29 = A. S.| last30 = Elliott| first30 = K. S.| display-authors = 29| doi = 10.1038/ng.140}}
17. ^{{cite web |url=https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=(RefNo==%27EC%2F2003%2F27%27) |title=EC/2003/27: O'Rahilly, Stephen Patrick |publisher=The Royal Society |archivedate=10 November 2014 |archiveurl=https://www.webcitation.org/6Tyav4bBu?url=https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=%28RefNo%3D%3D%27EC%2F2003%2F27%27%29 |location=London |deadurl=yes |df=dmy-all }}
18. ^Heinrich Wieland Prize {{webarchive |url=https://web.archive.org/web/20131112171407/http://www.heinrich-wieland-preis.de/index/getnews/id/7 |date=12 November 2013 }}
19. ^{{Cite journal | doi = 10.1242/dmm.006080 | title = Professor Stephen O'Rahilly wins the 2010 InBev-Baillet Latour Prize | journal = Disease Models & Mechanisms | volume = 3 | issue = 7–8 | pages = 402 | year = 2010 | pmid = 20610691 }}
20. ^{{cite web|url=http://deoec.hu/info.aspx?sp=82&web_id= |title=Debrecen Award for Molecular Medicine |publisher=University of Debrecen |accessdate=2015-01-07 |deadurl=yes |archiveurl=https://web.archive.org/web/20141213044251/http://www.deoec.hu/info.aspx?sp=82&web_id= |archivedate=2014-12-13 }}
21. ^{{cite web|title=Harveian Oration and dinner 2016|url=https://www.rcplondon.ac.uk/events/harveian-oration-and-dinner-2016|website=Royal College of Physician|accessdate=2016-11-28}}
22. ^{{London Gazette|issue=60534|supp=y|page=1|date=15 June 2013}}
23. ^[https://www.bbc.co.uk/news/health-22905680 Stephen O'Rahilly knighted], BBC News, 14 June 2013
{{FRS 2003}}{{Authority control}}{{DEFAULTSORT:ORahilly, Stephen}}

15 : People from County Dublin|Members of the United States National Academy of Sciences|Living people|Knights Bachelor|Fellows of the Academy of Medical Sciences|Fellows of the Royal College of Physicians|Fellows of the Royal College of Pathologists|Fellows of the Royal Society|Irish expatriates in the United Kingdom|20th-century Irish medical doctors|21st-century Irish medical doctors|Fellows of Pembroke College, Cambridge|Alumni of University College Dublin|1958 births|Irish diabetologists
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