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| Name = Succinate-semialdehyde dehydrogenase (acylating)
| EC_number = 1.2.1.76
| CAS_number =
| IUBMB_EC_number = 1/2/1/76
| GO_code =
| image =
| width =
| caption =
}}Succinate-semialdehyde dehydrogenase (acylating) ({{EC number|1.2.1.76}}, succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating).[1][2][3] This enzyme catalyses the following chemical reaction
succinate semialdehyde + CoA + NADP+succinyl-CoA + NADPH + H+
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.
References
1. ^{{cite journal | title = Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri |author1 = Sohling, B. |author2 =Gottschalk, G. |journal = Eur. J. Biochem. |year = 1993 |volume = 212 |pages = 121–127 |pmid = 8444151 |issue=1 |doi=10.1111/j.1432-1033.1993.tb17641.x}}
2. ^{{cite journal | title = Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp |author1 = Alber, B. |author2 =Olinger, M. |author3 =Rieder, A. |author4 =Kockelkorn, D. |author5 =Jobst, B. |author6 =Hugler, M. |author7 =Fuchs, G. | journal = J. Bacteriol. |year = 2006 |volume = 188 |pages = 8551–8559 |pmid = 17041055 |doi=10.1128/JB.00987-06 |pmc=1698253|url =http://oceanrep.geomar.de/6268/1/J.%20Bacteriol.-2006-Alber-8551-9.pdf }}
3. ^{{cite journal | title = A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea |author1 = Berg, I.A. |author2 =Kockelkorn, D. |author3 =Buckel, W. |author4 =Fuchs, G. |journal = Science |year = 2007 |volume = 318 |pages = 1782–1786 |pmid = 18079405 |doi=10.1126/science.1149976}}
2. ^{{cite journal | title = Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp |author1 = Alber, B. |author2 =Olinger, M. |author3 =Rieder, A. |author4 =Kockelkorn, D. |author5 =Jobst, B. |author6 =Hugler, M. |author7 =Fuchs, G. | journal = J. Bacteriol. |year = 2006 |volume = 188 |pages = 8551–8559 |pmid = 17041055 |doi=10.1128/JB.00987-06 |pmc=1698253|url =http://oceanrep.geomar.de/6268/1/J.%20Bacteriol.-2006-Alber-8551-9.pdf }}
3. ^{{cite journal | title = A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea |author1 = Berg, I.A. |author2 =Kockelkorn, D. |author3 =Buckel, W. |author4 =Fuchs, G. |journal = Science |year = 2007 |volume = 318 |pages = 1782–1786 |pmid = 18079405 |doi=10.1126/science.1149976}}
External links
- {{MeshName|Succinate-semialdehyde+dehydrogenase+(acylating)}}
1 : EC 1.2.1
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