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词条 Succinylation
释义

  1. References

  2. External links

Succinylation is a posttranslational modification where a succinyl group (-CO-CH2-CH2-CO2H) is added to a lysine residue of a protein molecule. This modification is found in many proteins, including histones.[1] The potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da), it is expected to lead to more significant changes in protein structure and function.[2]

By analogy to acetylation, it has been suggested that succinyl-CoA is the cofactor of enzyme-mediated lysine succinylation.

References

1. ^{{Cite journal | last1 = Xie | first1 = Z. | last2 = Dai | first2 = J. | last3 = Dai | first3 = L. | last4 = Tan | first4 = M. | last5 = Cheng | first5 = Z. | last6 = Wu | first6 = Y. | last7 = Boeke | first7 = J. D. | last8 = Zhao | first8 = Y. | title = Lysine succinylation and lysine malonylation in histones | doi = 10.1074/mcp.M111.015875 | journal = Molecular & Cellular Proteomics | year = 2012 | pmid = 22389435 | pmc = 3418837| volume=11 | issue=5 | pages=100–7}}
2. ^{{Cite journal | last1 = Zhang | first1 = Z. | last2 = Tan | first2 = M. | last3 = Xie | first3 = Z. | last4 = Dai | first4 = L. | last5 = Chen | first5 = Y. | last6 = Zhao | first6 = Y. | doi = 10.1038/nchembio.495 | title = Identification of lysine succinylation as a new post-translational modification | journal = Nature Chemical Biology | volume = 7 | issue = 1 | pages = 58–63 | year = 2010 | pmid = 21151122 | pmc =3065206 }}

External links

  • Succinylation, Yet A Novel PTM Pathway for Biological Regulation, But Ready to Be Investigated
  • Succinyl group at ChEBI
{{Protein posttranslational modification}}{{Posttranslational modification}}

1 : Posttranslational modification

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