| 词条 | Sulfanegen |
| 释义 |
| ImageFile = Sulfanegen.svg | ImageSize = 200px | ImageAlt = | IUPACName = 2,5-Dihydroxy-1,4-dithiane-2,5-dicarboxylic acid | OtherNames = |Section1={{Chembox Identifiers | CASNo = 80003-64-1 | CASNo_Comment = 1309654-46-3 for Na+ salt | PubChem = 24830990 | SMILES = C1C(SCC(S1)(C(=O)O)O)(C(=O)O)O | StdInChI=1S/C6H8O6S2/c7-3(8)5(11)1-13-6(12,2-14-5)4(9)10/h11-12H,1-2H2,(H,7,8)(H,9,10) | StdInChIKey= GYZMXMSJOZUNEQ-UHFFFAOYSA-N | ChemSpiderID = 29395474 | ChEBI = 138170 | InChI = 1/C6H8O6S2/c7-3(8)5(11)1-13-6(12,2-14-5)4(9)10/h11-12H,1-2H2,(H,7,8)(H,9,10) | InChIKey = GYZMXMSJOZUNEQ-UHFFFAOYAO }} |Section2={{Chembox Properties | C=6 | H=8 | O=6 | S=2 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Sulfanegen is an experimental antidote for cyanide poisoning.[1] It is being studied as a prodrug for 3-mercaptopyruvic acid (3-MP). 3-MP has been studied as a potential treatment for cyanide poisoning, but the half-life is too short for it to be clinically effective.[2] Instead, alternative chemicals such as sulfanegen, the hemithioacetal cyclic dimer of 3-MP, are being evaluated that produce 3-MP in vivo to compensate for the short half-life of 3-MP itself.[3] Sulfanegen has been shown to be effective in animal studies.[4] It is being studied as the disodium salt, sulfanegen sodium,[3][5] and the triethanolamine salt, sulfanegen TEA.[6] One advantage various sulfanegen formulations have over existing treatments for acute cyanide poisoning is that they might be administered by intramuscular injection or orally[1] rather than by intravenous infusion.[6] References1. ^1 {{cite web |url= http://www.medgadget.com/2007/12/scientists_discover_fastacting_cyanide_antidote.html |title= Scientists Discover Fast-Acting Cyanide Antidote | date = Dec 27, 2007 | publisher = Medgadget |accessdate= 2015-07-12 }} 2. ^{{cite journal | pmid = 12871026 | year = 2003 | last1 = Nagahara | first1 = N | last2 = Li | first2 = Q | last3 = Sawada | first3 = N | title = Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification? | volume = 3 | issue = 3 | pages = 198–204 | journal = Current drug targets. Immune, endocrine and metabolic disorders | doi=10.2174/1568008033340162}} 3. ^1 {{cite journal | pmid = 20705081 | year = 2010 | last1 = Brenner | first1 = M | last2 = Kim | first2 = JG | last3 = Lee | first3 = J | last4 = Mahon | first4 = SB | last5 = Lemor | first5 = D | last6 = Ahdout | first6 = R | last7 = Boss | first7 = GR | last8 = Blackledge | first8 = W | last9 = Jann | first9 = L | last10 = Nagasawa | first10 = HT | last11 = Patterson | first11 = SE | title = Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity | volume = 248 | issue = 3 | pages = 269–76 | doi = 10.1016/j.taap.2010.08.002 | pmc = 3382974 | journal = Toxicology and Applied Pharmacology}} 4. ^{{cite journal | pmid = 21740135 | year = 2011 | last1 = Chan | first1 = A | last2 = Crankshaw | first2 = DL | last3 = Monteil | first3 = A | last4 = Patterson | first4 = SE | last5 = Nagasawa | first5 = HT | last6 = Briggs | first6 = JE | last7 = Kozocas | first7 = JA | last8 = Mahon | first8 = SB | last9 = Brenner | first9 = M | last10 = Pilz | first10 = RB | last11 = Bigby | first11 = TD | last12 = Boss | first12 = GR | title = The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning | volume = 49 | issue = 5 | pages = 366–73 | doi = 10.3109/15563650.2011.584879 | journal = Clinical Toxicology | pmc=3882312}} 5. ^{{cite journal | pmid= 22392971 | year= 2012 | last1= Belani | first1= KG | last2= Singh | first2= H | last3= Beebe | first3= DS | last4= George | first4= P | last5= Patterson | first5= SE | last6= Nagasawa | first6= HT | last7= Vince | first7= R | title= Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium | volume= 114 | issue= 5 | pages= 956–61 | doi= 10.1213/ANE.0b013e31824c4eb5 | pmc= 3334426 | journal= Anesthesia and Analgesia}} 6. ^1 {{Cite news | url = https://news.yahoo.com/antidote-cyanide-found-132827160.html | publisher = Yahoo News | title = New Antidote for Cyanide Found | date = February 1, 2013}} 3 : Antidotes|Dithianes|Dicarboxylic acids |
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