| 词条 | Takashi Sugimura |
| 释义 |
|name = Takashi Sugimura |image = |image_size = |caption = |birth_date = April 20, 1926 |birth_place = Tokyo, Japan |death_date = |nationality = Japan |field = Biochemistry Cancer Research |work_institutions = National Cancer Center University of Tokyo Japanese Foundation for Cancer Research |alma_mater = University of Tokyo |known_for = Carcinogenesis |prizes = Charles S. Mott Prize (1981) Japan Prize (1997) }}{{Nihongo|Takashi Sugimura|杉村 隆|Sugimura Takashi|born April 20, 1926}} is a Japanese biochemist, famous for research on chemical carcinogens. He received the Japan Prize for the contribution to establishment of fundamental concept on causes of cancer.[1] He was elected as President of the Japan Academy on October 15, 2013.[2] ContributionSugimura isolated and identified many mutagens with a structure of heterocyclic amine from foods cooked under ordinary conditions. He showed that tumors induced by these heterocyclic amines had genetic alterations. He further developed his studies to analyze multiple-step carcinogenesis at molecular levels to promote effective primary prevention of cancer.[3] His group identified the novel polymer poly(ADP-ribose) and demonstrated the presence of the enzyme poly ADP ribose polymerase (PARP). He also discovered the cognate catabolic enzyme, poly(ADP-ribose) glycohydrolase (PARG) and further elucidated the biology of poly(ADP-ribose). The astonishing discovery of pierisin, an apoptogenic peptide that ADP-ribosyaltes DNA, profoundly illuminates his scientific character and curiosity as well.[4] BiographySugimura completed his M.D. in 1949 from the Faculty of Medicine, University of Tokyo, and received the degree of Doctor of Medical Science in 1957 from the same institution.[1] After his postdoctoral fellowship at the Cancer Institute, Japanese Foundation for Cancer Research, he became Chief of Biochemistry Division at the Research Institute, National Cancer Center in Tokyo in 1962, where he served as President from 1984 to 1991.[5] In addition, he was Professor of Institute of Medical Science, University of Tokyo from 1970 to 1985 and President of Toho University from 1994 to 2000.[5] He is Fellow of the American Association for Cancer Research (AACR) Academy,[3] Honorary Member of Japanese Cancer Association.[6] and also President Emeritus of National Cancer Center. RecognitionSugimura received numerous awards and honors include the following: Awards
Honors
See also
References1. ^1 2 Dr. Takashi Sugimura 1997 (13th) Japan Prize Laureate {{Authority control}}{{DEFAULTSORT:Sugimura, Takashi}}2. ^日本学士院長の選定について Selection of President of the Japan Academy{{ja icon}} 3. ^1 Fellows of the AACR Academy 4. ^{{Cite journal | doi = 10.1093/jb/mvs005| title = The pioneering spirit of Takashi Sugimura: His studies of the biochemistry of poly(ADP-ribosylation) and of cancer| journal = Journal of Biochemistry| volume = 151| issue = 3| pages = 221| year = 2012| last1 = Masutani | first1 = M.| pmid=22375027}} 5. ^1 "チョウとがんと未知なるものと私" Biography of Takashi Sugimura{{ja icon}} 6. ^日本癌学会|名誉会員 Honorary Members of the Japanese Cancer Association{{ja icon}} 7. ^Personal Information | The Japan Academy 8. ^{{cite web|author= |url=https://www.knaw.nl/nl/leden/buitenlandse-leden/4843 |title=T. Sugimura |language=Dutch |publisher=Royal Netherlands Academy of Arts and Sciences |date= |accessdate=12 July 2015}} 12 : 1926 births|Living people|Cancer researchers|Japanese biochemists|Members of the United States National Academy of Sciences|Members of the Royal Netherlands Academy of Arts and Sciences|Members of the Royal Swedish Academy of Sciences|Members of the National Academy of Medicine|Laureates of the Imperial Prize|Recipients of the Order of Culture|University of Tokyo faculty|University of Tokyo alumni |
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