| 词条 | TAPI-1 |
| 释义 |
| Name = TAPI-1 | ImageFile = TAPI-1.svg | ImageSize = | ImageAlt = | SystematicName = N(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methylpentanoyl3-(2-naphthyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide | OtherNames = |Section1={{Chembox Identifiers | CASNo = 163847-77-6 | PubChem = 10458621 | ChemSpiderID = 8634035 | SMILES = O=C(NCCN)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](CC(=O)NO)CC(C)C)Cc2ccc1c(cccc1)c2)C | InChI = 1/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21+,22-/m0/s1 | InChIKey = AWNBSWDIOCXWJW-WTOYTKOKBP | StdInChI = 1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21+,22-/m0/s1 | StdInChIKey = AWNBSWDIOCXWJW-WTOYTKOKSA-N}} |Section2={{Chembox Properties | C=26 | H=37 | N=5 | O=5 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}TAPI-1 ( TNF-alpha protease inhibitor I) is a structural analog of TAPI-0 with similar but more stable validness{{clarify|reason=What does "more stable validness" mean?|date=September 2014}} in vitro for the matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme[1] which blocks shedding of several cell surface proteins such as IL-6 and p60 TNF receptor.[2] References1. ^{{cite journal|title=A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor|author=Müllberg J rt al|date=Dec 1, 1995|journal=J Immunol|volume=155|issue=11|pages=5198–5205|pmid=7594530|last2=Durie|last3=Otten-Evans|last4=Alderson|last5=Rose-John|last6=Cosman|last7=Black|last8=Mohler}} 2. ^{{cite web|url=http://www.selleckchem.com/products/tapi-1.html|title=TAPI-1 biological activity|publisher=selleckchemicals}} 3 : TNF inhibitors|Hydroxamic acids|Naphthalenes |
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